H
Haiyong Han
Researcher at Translational Genomics Research Institute
Publications - 100
Citations - 7812
Haiyong Han is an academic researcher from Translational Genomics Research Institute. The author has contributed to research in topics: Pancreatic cancer & Cancer. The author has an hindex of 42, co-authored 100 publications receiving 6779 citations. Previous affiliations of Haiyong Han include University of Texas at Austin & University of Arizona.
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Journal ArticleDOI
G-quadruplex DNA: a potential target for anti-cancer drug design
Haiyong Han,Laurence H. Hurley +1 more
TL;DR: The possible role of G-quadruplex-interactive compounds as pharmacologically important molecules is explored in this article.
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Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer
Clifford J. Whatcott,Caroline H. Diep,Ping Jiang,Aprill Watanabe,Janine LoBello,Chao Sima,Galen Hostetter,H. Michael Shepard,Daniel D. Von Hoff,Haiyong Han +9 more
TL;DR: The results suggest that both primary tumors and metastases of PDAC have highly fibrotic stroma, and stromal targeting agents have the potential to benefit PDAC patients, even those with metastatic disease.
Journal ArticleDOI
Cationic Porphyrins as Telomerase Inhibitors: the Interaction of Tetra-(N-methyl-4-pyridyl)porphine with Quadruplex DNA
Journal Article
Identification of Differentially Expressed Genes in Pancreatic Cancer Cells Using cDNA Microarray
Haiyong Han,David J. Bearss,L. Walden Browne,Robert Calaluce,Raymond B. Nagle,Daniel D. Von Hoff +5 more
TL;DR: In this paper, the authors compared the gene expression patterns of pancreatic cancer cell lines growing in tissue culture with those of normal pancreas using cDNA microarray analysis, and the expression ratios of neoplastic versus normal pancreatreas cells were then calculated by multiplying the ratio of cancer versus the universal reference mRNA and the ratios of the universal-reference mRNA cell versus normal-pancreas.
Journal ArticleDOI
NMR-Based Model of a Telomerase-Inhibiting Compound Bound to G-Quadruplex DNA†
Oleg Yu. Fedoroff,Miguel Salazar,Haiyong Han,Violetta V. Chemeris,Sean M. Kerwin,Laurence H. Hurley +5 more
TL;DR: 3,4,9, 10-perylenetetracarboxylic diimide-based ligands are identified as potent inhibitors of human telomerase by using a primer extension assay that does not use PCR-based amplification of the telomersase primer extension products.