Hak Jun Kim

TL;DR: The three-dimensional structure of the DAGK homotrimer is determined with the use of solution nuclear magnetic resonance, providing insight into the determinants of lipid substrate specificity and phosphotransferase activity.

TL;DR: Docking to open KCNQ1 indicates that the extracellular end of the KCNE1 TMD forms an interface with an intersubunit cleft in the channel that is associated with most known gain-of-function disease mutations.

TL;DR: It is proposed that APP may serve as a cellular cholesterol sensor that is linked to mechanisms for suppressing cellular cholesterol uptake, and may be critical for the trafficking of these proteins to cholesterol-rich membrane domains, which leads to cleavage by beta- and gamma-secretase and resulting amyloid-beta production.

TL;DR: Recent progress in the application of solution NMR of IMPs is highlighted to outline sample preparative and spectroscopic advances that have led to this breakthrough and there is reason to believe that this recent progress reflects only the beginning of a phase of exponential growth in the use of solutions NMR methods to solve important problems in membrane protein structural biology.

TL;DR: The structure and function of marine-derived AFPs are reviewed, including moderately active fish AFPs and hyperactive polar AFPs, as well as previous and current reports of cryopreservation using AFPs.