H
Halina Offner
Researcher at Oregon Health & Science University
Publications - 6
Citations - 1071
Halina Offner is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Estrogen receptor alpha. The author has an hindex of 5, co-authored 6 publications receiving 979 citations. Previous affiliations of Halina Offner include Veterans Health Administration.
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Journal ArticleDOI
Cutting Edge: Estrogen Drives Expansion of the CD4+CD25+ Regulatory T Cell Compartment
Magdalena J. Polanczyk,Bryan Carson,Bryan Carson,Sandhya Subramanian,Michael Afentoulis,Arthur A. Vandenbark,Arthur A. Vandenbark,Steven F. Ziegler,Steven F. Ziegler,Halina Offner +9 more
TL;DR: The data suggest E2 promotes tolerance by expanding the regulatory T cell compartment by augmenting FoxP3 expression in vitro and in vivo, suggesting that high estrogen levels during pregnancy may help to maintain fetal tolerance.
Journal ArticleDOI
Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice
Magdalena J. Polanczyk,Magdalena J. Polanczyk,Corwyn Hopke,Jianya Huan,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner +7 more
TL;DR: E2 treatment may have opposing effects on Treg cells vs. APC that both contribute to overt suppression, but such effects are overcome and focused towards enhanced suppression in inflammatory environments produced during pregnancy and EAE.
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Estrogen inhibition of EAE involves effects on dendritic cell function.
Hong Yan Liu,Abigail C. Buenafe,Abigail C. Buenafe,Agata Matejuk,Agata Matejuk,Agata Matejuk,Atsushi Ito,Atsushi Ito,Alex Zamora,Alex Zamora,Jami Dwyer,Jami Dwyer,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner +15 more
TL;DR: E2 treatment appears to have multiple effects on the DC population, which may contribute to a down‐regulation or block in the activation of Th1 cells involved in the induction of EAE.
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The Protective Effect of 17β-Estradiol on Experimental Autoimmune Encephalomyelitis Is Mediated through Estrogen Receptor-α
Magdalena J. Polanczyk,Magdalena J. Polanczyk,Alex Zamora,Alex Zamora,Sandhya Subramanian,Agata Matejuk,Agata Matejuk,David L. Hess,Elizabeth P. Blankenhorn,Cory Teuscher,Arthur A. Vandenbark,Arthur A. Vandenbark,Halina Offner,Halina Offner +13 more
TL;DR: The results indicate that the immunomodulatory effects of E2 in EAE are dependent on Esr1 and not Esr2 signaling, which is in contrast to C57BL/6 wild-type (WT) mice and Esr/− mice in which E2 treatment resulted in comparable serum levels and markedly suppressed clinical signs of EAE and abolished inflammatory lesions in the CNS.
Journal ArticleDOI
Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis.
TL;DR: The protective effects of E2 in EAE suggest its use as therapy for MS, although the risk of cardiovascular disease may complicate treatment in postmenopausal women.