H
Hamish Simpson
Researcher at University of Edinburgh
Publications - 88
Citations - 3293
Hamish Simpson is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Distraction osteogenesis & Cortical bone. The author has an hindex of 23, co-authored 84 publications receiving 2931 citations. Previous affiliations of Hamish Simpson include Nuffield Orthopaedic Centre & Royal Hospital for Sick Children.
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Journal ArticleDOI
Prospective evaluation of criteria for microbiological diagnosis of prosthetic-joint infection at revision arthroplasty. The OSIRIS Collaborative Study Group.
Bridget L. Atkins,Nicholas A. Athanasou,Jonathan J Deeks,Derrick W. Crook,Hamish Simpson,Tim E. A. Peto,Peter McLardy-Smith,Anthony R. Berendt,Anthony R. Berendt +8 more
TL;DR: It is recommended that five or six specimens be sent, that the cutoff for a definite diagnosis of infection be three or more operative specimens that yield an indistinguishable organism, and that because of its low level of sensitivity, Gram staining should be abandoned as a diagnostic tool at elective revision arthroplasty.
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Delayed union and nonunions: epidemiology, clinical issues, and financial aspects.
David J. Hak,Daniel C. Fitzpatrick,Julius A. Bishop,J. Lawrence Marsh,Susanne Tilp,Reinhard Schnettler,Hamish Simpson,Volker Alt +7 more
TL;DR: All strategies that help to reduce healing time with faster resumption of work and activities not only improve medical outcome for the patient, they also help reduce the financial burden in fracture and non-union patients.
Journal ArticleDOI
Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch.
TL;DR: To ascertain if IGF-1 is a regulator of local muscle growth, total RNA was extracted from rabbit muscle induced to undergo rapid hypertrophy using active stretch and from control muscles to confirm that alternative splicing of the insulin-like growth factor 1 gene occurs in muscle in response to physical activity.
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Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch.
TL;DR: The data suggest that the expression of IGF‐I within individual muscle fibres is correlated not only with hypertrophy but also with the muscle phenotypic adaptation that results from stretch and overload.
Journal ArticleDOI
Cellular and Molecular Anatomy of the Human Neuromuscular Junction
Ross A. Jones,Carl Harrison,Samantha L. Eaton,Maria del carmen Llavero hurtado,Laura C. Graham,Leena Alkhammash,Oladayo A. Oladiran,Andy Gale,Douglas J. Lamont,Hamish Simpson,Martin W. Simmen,Christian Soeller,Thomas M. Wishart,Thomas H. Gillingwater +13 more
TL;DR: Human NMJs were significantly smaller, less complex, and more fragmented than mouse NMJs, and remarkably stable across the entire adult lifespan, showing no signs of age-related degeneration or remodeling.