H
Han Li
Researcher at University of California, Irvine
Publications - 28
Citations - 1395
Han Li is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Cofactor & Nicotinamide mononucleotide. The author has an hindex of 10, co-authored 24 publications receiving 1074 citations. Previous affiliations of Han Li include University of California, Berkeley & University of California, Los Angeles.
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Journal ArticleDOI
Integrated Electromicrobial Conversion of CO2 to Higher Alcohols
Han Li,Paul H. Opgenorth,David G. Wernick,Steve Rogers,Tung-Yun Wu,Wendy Higashide,Peter Malati,Yi-Xin Huo,Kwang Myung Cho,James C. Liao +9 more
TL;DR: This work genetically engineered a lithoautotrophic microorganism, Ralstonia eutropha H16, to produce isobutanol and 3-methyl-1-butanol in an electro-bioreactor, opening the possibility of electricity-driven bioconversion of CO2 to commercial chemicals.
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Expanding metabolism for total biosynthesis of the nonnatural amino acid L-homoalanine.
TL;DR: The natural metabolic capability to biosynthesize a nonnatural amino acid L-homoalanine, which is a chiral precursor of levetiracetam, brivaracetol, and ethambutol, is expanded and opens the possibility of total biosynthesis of other nonnatural chiral compounds that could be useful pharmaceutical intermediates.
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Engineering a cyanobacterium as the catalyst for the photosynthetic conversion of CO2 to 1,2-propanediol
Han Li,James C. Liao +1 more
TL;DR: This work demonstrated that cyanobacteria can be engineered as a catalyst for the photosynthetic conversion of CO2 to 1,2-PDO, and characterized two NADPH-dependent sADHs for their catalytic capacity in 1,1- PDO formation, and suggested that they may be useful tools for renewable production of reduced chemicals in photosynthetics organisms.
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A synthetic recursive "+1" pathway for carbon chain elongation.
Ryan J. Marcheschi,Han Li,Kechun Zhang,Elizabeth L. Noey,Seonah Kim,Asha Chaubey,Kendall N. Houk,James C. Liao,James C. Liao +8 more
TL;DR: This work has engineered the enzymes involved in leucine biosynthesis for use as a synthetic "+1" recursive metabolic pathway to extend the carbon chain of 2-ketoacids, and preferentially selects longer-chain substrates for catalysis.
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Biofuels: biomolecular engineering fundamentals and advances.
TL;DR: The biological production of fuels from renewable sources has been regarded as a feasible solution to the energy and environmental problems in the foreseeable future, and the biofuel product spectrum has expanded from ethanol and fatty acid methyl esters to other molecules, such as higher alcohols and alkanes, with more desirable fuel properties.