Hana Jelínková

TL;DR: The proposed high‐throughput sequencing based method for the identification of clonal TRA gene rearrangements at the DNA level fills the existing gap in utilizing the TRA gene for a wide range of studies, including clonality assessment, MRD monitoring and clonal evolution analysis in different lymphoid malignancies.

TL;DR: The LYNX panel as discussed by the authors is an integrative, custom-designed, capture-based NGS panel for the analysis of standard and novel molecular markers in the most common lymphoid neoplasms (chronic lymphocytic leukemia, acute lymphoblastic leukemia, diffuse large B-cell lymphoma, follicular lymphoma and mantle cell lymphoma).

TL;DR: An analysis comparing the importance of flow cytometry (FCM) and real‐time quantitative polymerase chain reaction (PCR) in the assessment of MRD in adult ALL showed that both FCM and PCR MRD assessment methods are sensitive for survival prediction during induction.

TL;DR: Near‐haploid acute lymphoblastic leukemia is rare subgroup of the disease, which is very important due to very poor prognosis and resistance to treatment including novel monoclonal antibodies and CAR‐T therapy.

TL;DR: In this article, the frequency and mutual associations of BCR-ABL1-like acute lymphoblastic leukemia (ALL) with a complex genomic background were studied, and the authors found that the frequency of mutations was positively associated with the survival of ALL patients.