Hang Ji

TL;DR: In this article, the m6A RNA methylation is used to predict the molecular subtypes of low-grade glioma, the abundance of immune infiltration, the enrichment of signaling pathways, gene variation and prognosis.

TL;DR: It is revealed that the 13 central m6A RNA methylation regulators were firmly related to the clinical and molecular phenotype of GBM, and are a type of vital participant in the malignant progression ofGBM, with a critical potential in the prognostic stratification and treatment strategies of G BM.

TL;DR: Survival analysis and experimental data confirmed that the five hub genes could be used as markers for poor prognosis of GBM, and the results based on an in vivo xenograft model are consistent with the finding that knockdown of the hub gene inhibits the growth of GSCs in vitro.

TL;DR: The results revealed the molecular basis of LGG, provided valuable clues for the understanding of m5C-related lncRNAs, and filled a gap between epigenetics and tumor microenvironment.

TL;DR: Wang et al. as discussed by the authors identified four overexpressed and mutated tumor antigens associated with poor prognosis and infiltration of antigen presenting cells, including TP53, IDH1, C3, and TCF12, and four immune subtypes of glioma (IS1-IS4 and 10 immune gene modules were identified consistently in the TCGA data.