H
Hanna Appelqvist
Researcher at Linköping University
Publications - 23
Citations - 1837
Hanna Appelqvist is an academic researcher from Linköping University. The author has contributed to research in topics: Autophagy & NPC1. The author has an hindex of 14, co-authored 23 publications receiving 1577 citations.
Papers
More filters
Journal ArticleDOI
The lysosome: from waste bag to potential therapeutic target
TL;DR: This review focuses on lysosomal involvement in digestion of intra- and extracellular material, plasma membrane repair, cholesterol homeostasis, and cell death.
Journal ArticleDOI
Regulation of apoptosis-associated lysosomal membrane permeabilization
Ann-Charlotte Johansson,Hanna Appelqvist,Cathrine Nilsson,Katarina Kågedal,Karin Roberg,Karin Öllinger +5 more
TL;DR: A growing body of evidence suggests that LMP may be governed by several distinct mechanisms that are likely engaged in a death stimulus- and cell-type-dependent fashion, and factors contributing to permeabilization of the lysosomal membrane including reactive oxygen species, lysOSomal membrane lipid composition, proteases, p53, and Bcl-2 family proteins are described.
Journal ArticleDOI
Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death.
TL;DR: The present review summarizes the current knowledge on the targeting and permeabilizing properties of lysosomotropic detergents from a cellular and physicochemical perspective.
Journal ArticleDOI
Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease.
Andrea Armstrong,Niklas Mattsson,Niklas Mattsson,Hanna Appelqvist,Camilla Janefjord,Linnea Sandin,Lotta Agholme,Bob Olsson,Samuel P.S. Svensson,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg,Katarina Kågedal +12 more
TL;DR: Findings indicate that increased levels of LAMP-1, Lamp-2, LC3, Rab3 and Rab7 in the CSF might be specific for AD, and increased EEA1 levels may be a sign of general neurodegeneration.
Journal ArticleDOI
Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation
Hanna Appelqvist,Cathrine Nilsson,Brett Garner,Brett Garner,Andrew J. Brown,Katarina Kågedal,Karin Öllinger +6 more
TL;DR: Investigation of the importance of cholesterol in the regulation of lysosomal membrane permeability and its potential impact on apoptosis found cholesterol accumulation in lYSosomes attenuates apoptosis by increasing lysOSomal membrane stability.