Karin Öllinger

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This review focuses on lysosomal involvement in digestion of intra- and extracellular material, plasma membrane repair, cholesterol homeostasis, and cell death.

TL;DR: A growing body of evidence suggests that LMP may be governed by several distinct mechanisms that are likely engaged in a death stimulus- and cell-type-dependent fashion, and factors contributing to permeabilization of the lysosomal membrane including reactive oxygen species, lysOSomal membrane lipid composition, proteases, p53, and Bcl-2 family proteins are described.

TL;DR: The potential use of resveratrol as a chemotherapeutic agent in breast cancers is supported by the observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERalpha- ERbeta+ MDA-MB-231 tumors in resver atrol-treated nude mice compared with controls.

TL;DR: It is suggested that translocation of lysosomal proteases is an early event in NZ‐induced apoptosis and that the release and increased activity of cathepsin D allow this protease to exert an apoptosis‐mediating effect upstream of the caspase cascade.