H
Hannah R. Bridges
Researcher at MRC Mitochondrial Biology Unit
Publications - 32
Citations - 1463
Hannah R. Bridges is an academic researcher from MRC Mitochondrial Biology Unit. The author has contributed to research in topics: Electron Transport Complex I & Biology. The author has an hindex of 16, co-authored 23 publications receiving 1017 citations. Previous affiliations of Hannah R. Bridges include Medical Research Council & University of Cambridge.
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Journal ArticleDOI
Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria.
TL;DR: It is reported that biguanides inhibit complex I by inhibiting ubiquinone reduction (but not competitively) and, independently, stimulate reactive oxygen species production by the complex I flavin and are identified as a new class of complex I and ATP synthase inhibitor.
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Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states
Ahmed-Noor A. Agip,James N. Blaza,Hannah R. Bridges,Carlo Viscomi,Shaun Rawson,Stephen P. Muench,Judy Hirst +6 more
TL;DR: The 3.3-A structure of complex I from mouse heart mitochondria, a biomedically relevant model system, is described and a nucleotide bound in subunit NDUFA10, a nucleoside kinase homolog, is revealed, and mechanistically critical elements in the mammalian enzyme are defined.
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Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.
TL;DR: Biguanides inhibit mitochondrial complex I, but specific molecular features control the uptake of substituted biguanides into mitochondria, so only some biguanided inhibit mitochondrial respiration in vivo, suggesting that biguanide uptake into mitochondia is protein mediated, and is not by passive diffusion.
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Structure of inhibitor-bound mammalian complex I
Hannah R. Bridges,Justin G. Fedor,James N. Blaza,James N. Blaza,Andrea Di Luca,Andrea Di Luca,Alexander Jussupow,Owen D. Jarman,John J. Wright,John J. Wright,Ahmed-Noor A. Agip,Ana P. Gamiz-Hernandez,Ana P. Gamiz-Hernandez,Maxie M. Roessler,Ville R. I. Kaila,Ville R. I. Kaila,Judy Hirst +16 more
TL;DR: This work describes the 3.0-Å resolution cryo-EM structure of complex I from mouse heart mitochondria with a substrate-like inhibitor, piericidin A, bound in the ubiquinone-binding active site and provides evidence that two inhibitor molecules bind end-to-end in the long substrate binding channel.
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Structural basis for a complex I mutation that blocks pathological ROS production
Zhan Yin,Nils Burger,Duvaraka Kula-Alwar,Dunja Aksentijevic,Hannah R. Bridges,Hiran A. Prag,Daniel N. Grba,Carlo Viscomi,Carlo Viscomi,Andrew M. James,Amin Mottahedin,Amin Mottahedin,Amin Mottahedin,Thomas Krieg,Michael P. Murphy,Michael P. Murphy,Judy Hirst +16 more
TL;DR: In this article, the effects of a P25L mutation in the ND6 subunit of the mitochondria of the mtDNA point mutation were investigated in the context of myocardial infarction.