H
Hanne C.G. Birkeland
Researcher at University of Oslo
Publications - 2
Citations - 666
Hanne C.G. Birkeland is an academic researcher from University of Oslo. The author has contributed to research in topics: Aggrephagy & Endosome. The author has an hindex of 2, co-authored 2 publications receiving 621 citations.
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Journal ArticleDOI
The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
Maria Filimonenko,Pauline Isakson,Kim D. Finley,Monique Anderson,Hyun Jeong,Thomas J. Melia,Bryan J. Bartlett,Katherine M. Myers,Hanne C.G. Birkeland,Trond Lamark,Dimitri Krainc,Andreas Brech,Harald Stenmark,Anne Simonsen,Ai Yamamoto +14 more
TL;DR: Alfy, a phosphatidylinositol 3-phosphate-binding protein, is central to the selective elimination of aggregated proteins and proposed that Alfy plays a key role in selective macroautophagy by bridging cargo to the molecular machinery that builds autophagosomes.
Journal ArticleDOI
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes
Anne Simonsen,Hanne C.G. Birkeland,David J. Gillooly,Noboru Mizushima,Noboru Mizushima,Akiko Kuma,Tamotsu Yoshimori,Thomas Slagsvold,Andreas Brech,Harald Stenmark +9 more
TL;DR: A novel giant FYVE-domain-containing protein, named autophagy-linked FYVE protein (Alfy), which is ubiquitously expressed, shares sequence similarity with the Chediak-Higashi-syndrome protein and has putative homologues in flies, nematodes and fission yeast is described.