H
Hans Ackerman
Researcher at National Institutes of Health
Publications - 52
Citations - 3741
Hans Ackerman is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Population & Haplotype. The author has an hindex of 19, co-authored 45 publications receiving 3435 citations. Previous affiliations of Hans Ackerman include Wellcome Trust Centre for Human Genetics & University of Oxford.
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Journal ArticleDOI
Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease.
Alexander M. Gorbach,Hans Ackerman,Wei-Min Liu,Joseph Meyer,Patricia Littel,Catherine Seamon,Eleni Footman,Amy Chi,Suzana M. Zorca,Megan L. Krajewski,Michael J. Cuttica,Roberto F. Machado,Richard O. Cannon,Gregory J. Kato +13 more
TL;DR: IR imaging of agonist-stimulated cutaneous blood flow represents a less cumbersome alternative to plethysmography methodology and may be a useful new marker of vascular risk in adults with SCD.
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The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria: a prospective, multicentre observational study.
Hans Ackerman,Aintzane Ayestaran,Olola Cho.,Muminatou Jallow,Tsiri Agbenyega,Kalifa Bojang,David J. Roberts,Sanjeev Krishna,Peter G. Kremsner,Charles R. Newton,Terrie E. Taylor,Clarissa Valim,Climent Casals-Pascual +12 more
TL;DR: The findings suggest that whole blood transfusion was associated with improved survival among children hospitalised with P falciparum malaria, and among those with impaired consciousness or hyperlactataemia, transfusionwas associated with better survival at haemoglobin concentrations above the currently recommended transfusion threshold.
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Antioxidant therapy: reducing malaria severity?
TL;DR: Treatment with N-acetyl-cysteine (NAC) was expected to improve RBC deformability and oxygen delivery in vivo and hypothesized that decreased deformability impedes the transit of RBCs through capillaries, impairing oxygen delivery.
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Microvascular oxygen consumption during sickle cell pain crisis.
Carol A. Rowley,Allison K. Ikeda,Miles Seidel,Tiffany C. Anaebere,Matthew D. Antalek,Catherine Seamon,Anna Conrey,Laurel Mendelsohn,James S. Nichols,Alexander M. Gorbach,Gregory J. Kato,Hans Ackerman +11 more
TL;DR: Microvascular oxygen consumption was greater in sickle cell patients than in healthy individuals and was elevated further during acute pain crisis and could affect the local oxygen saturation of hemoglobin when oxygen delivery is limiting.
Journal ArticleDOI
Biochemical characterization of AeD7L2 and its physiological relevance in blood feeding in the dengue mosquito vector, Aedes aegypti.
Ines Martin-Martin,Olivia Kern,Steven E. Brooks,Leticia Barion Smith,Paola Carolina Valenzuela-Leon,Brian Bonilla,Hans Ackerman,Eric Calvo +7 more
TL;DR: The different ligand specificity and affinities of AeD 7L1 and AeD7L2 matched the experimental observations from studying their effects on vasoconstriction and platelet aggregation, which confirm their role in preventing host hemostasis.