H
Hans De Winter
Researcher at University of Antwerp
Publications - 53
Citations - 1364
Hans De Winter is an academic researcher from University of Antwerp. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 17, co-authored 46 publications receiving 1122 citations. Previous affiliations of Hans De Winter include Monash University, Parkville campus & Johnson & Johnson Pharmaceutical Research and Development.
Papers
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Reference BookDOI
Computational Medicinal Chemistry for Drug Discovery
TL;DR: This reference offers the techniques most frequently utilized by industry and academia for ligand design, including molecular mechanics, semi-empirical methods, wave function-based quantum chemistry, density functional theory, 3-D structure generation, and hybrid methods.
Journal ArticleDOI
2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
Ellen W. Baxter,Kelly A. Conway,Ludo Edmond Josephine Kennis,François Paul Bischoff,Marc Mercken,Hans De Winter,Charles H. Reynolds,Brett A. Tounge,Chi Luo,Malcolm K. Scott,Yifang Huang,Mirielle Braeken,Serge Maria Aloysius Pieters,Didier Berthelot,Stefan Masure,Wouter David Bruinzeel,Alfonzo D. Jordan,Michael H. Parker,Robert E. Boyd,Junya Qu,Richard S. Alexander,Douglas E. Brenneman,Allen B. Reitz +22 more
TL;DR: A new aspartic protease inhibitory chemotype bearing a 2-amino-3,4-dihydroquinazoline ring was identified by high-throughput screening for the inhibition of BACE-1 and its potency was increased by substitution into the unoccupied S(1)' pocket.
Patent
Sulfonyl-derivatives as novel inhibitors of histone deacetylase
Kristof Van Emelen,Janine Arts,Leo Jacobus Jozef Backx,Hans De Winter,Sven Franciscus Anna Van Brandt,Marc Gustaaf Celine Verdonck,Lieven Meerpoel,Isabelle Noelle Constance Pilatte,Virginie Sophie Poncelet,Alexey B. Dyatkin,Jimmy Arnold Viviane Van heusden +10 more
TL;DR: In this paper, the novel compounds of formula (I) have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing them and their use as a medicine.
Journal ArticleDOI
Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma.
Kenneth Verstraete,Frank Peelman,Harald Braun,Juan José Marín López,Dries Van Rompaey,Ann Dansercoer,Isabel Vandenberghe,Kris Pauwels,Jan Tavernier,Bart N. Lambrecht,Bart N. Lambrecht,Hamida Hammad,Hamida Hammad,Hans De Winter,Rudi Beyaert,Guy Lippens,Savvas N. Savvides +16 more
TL;DR: A fusion protein comprising a tandem of the TSLPR and IL-7Rα extracellular domains is introduced, which harnesses the mechanistic intricacies ofThe TSLP-driven receptor complex to manifest high antagonistic potency.
Journal ArticleDOI
Pharao: pharmacophore alignment and optimization.
TL;DR: Within the context of early drug discovery, a new pharmacophore-based tool to score and align small molecules (Pharao) is described, built on the idea to model pharmacophoric features by Gaussian 3D volumes instead of the more common point or sphere representations.