Hans Iding

TL;DR: This Review focuses on efforts to combine chemo- and biocatalysts, outlining the opportunities achievable by this approach and also efforts to overcome any incompatibilities between these different systems.

TL;DR: The creation of highly active and stereoselective transaminases starting from fold class I are reported and can be engineered into other protein scaffolds with sequence identities as low as 70%, and should have a broad impact in the field of biocatalytic synthesis and enzyme engineering.

TL;DR: A new enzyme tool comprising a vast applicability for stereoselective synthesis and a simple way to increase the enantiomeric excess of (S)-2-hydroxy-1-phenyl-propanone from 90% to 95% by skillful choice of the reaction parameters is presented.

TL;DR: Comparison of the X-ray structures of both enzymes identified two residues in each that were likely to be involved in determining substrate specificity that proved to be a real chimera between PDC and BFD and provided the most interesting result with an almost complete reversal of the stereochemistry of its 2-hydroxypropiophenone product.

TL;DR: The evolution of the synthesis of oseltamivir phosphate (Tamiflu®) used for the oral treatment and prevention of influenza virus infections (viral flu) is described in this article.