Hao Zhou

TL;DR: It is shown that acute administration of angiopoietin-1 does indeed protect adult vasculature from leaking, countering the potentially lethal actions of VEGF and inflammatory agents.

TL;DR: The results provide genetic evidence that H-RasV12G is important in both the genesis and maintenance of solid tumours, and the failure of persistent endogenous and enforced VEGF expression to sustain tumour viability indicates that the tumour-maintaining actions of activated Ras extend beyond the regulation of V EGF expression in vivo.

TL;DR: It is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels, raising the possibility that angioietins can be used, alone or in combination with VEGF to promote therapeutic angiogenesis.

TL;DR: The angiopoietins have recently joined the members of the vascular endothelial growth factor family as the only known growth factors largely specific for vascular endothelium as discussed by the authors, and they include a naturally occurring agonist, angioietin-1, as well as an naturally occurring antagonist, angiopooietin2, both of which act by means of the Tie2 receptor.

TL;DR: Attempts to use homology-based cloning approaches to identify new members of the angiopoietin family are reported, leading to the identification of two new angioietins that appear to represent the mouse and human counterparts of the same gene locus.