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Aldrich Thomas H
Researcher at Regeneron
Publications - 34
Citations - 11236
Aldrich Thomas H is an academic researcher from Regeneron. The author has contributed to research in topics: Receptor tyrosine kinase & Ligand (biochemistry). The author has an hindex of 20, co-authored 34 publications receiving 10959 citations. Previous affiliations of Aldrich Thomas H include Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
Journal ArticleDOI
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Samuel Davis,Aldrich Thomas H,Pamela F. Jones,Ann Acheson,Debra L Compton,Vivek Jain,Terence E Ryan,Joanne Bruno,Czeslaw Radziejewski,Maisonpierre Peter C,George D. Yancopoulos +10 more
TL;DR: The identification of a secreted ligand for TIE2, termed Angiopoietin-1, is reported using a novel expression cloning technique that involves intracellular trapping and detection of the ligand in COS cells.
Journal ArticleDOI
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
Stephen P. Squinto,Trevor Stitt,Aldrich Thomas H,Samuel Davis,Stella M. Blanco,Czeslaw Radziejewski,David J. Glass,Piotr Masiakowski,Mark E. Furth,David M. Valenzuela,Peter S. DiStefano,George D. Yancopoulos +11 more
TL;DR: It is demonstrated that all three of these neuronal survival molecules bind similarly to the low affinity NGF receptor, but that BDNF and NT-3, unlike NGF, do not act via the high affinity N GF receptor.
Journal ArticleDOI
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.
Samuel Davis,Nicholas W. Gale,Aldrich Thomas H,Maisonpierre Peter C,Vladimir Lhotak,Tony Pawson,Mitchell Goldfarb,George D. Yancopoulos +7 more
TL;DR: A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified, suggesting that they require direct cell-to-cell contact to activate their receptors.
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LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.
Samuel Davis,Aldrich Thomas H,Neil Stahl,Li Pan,Tetsuya Taga,Tadamitsu Kishimoto,Nancy Y. Ip,George D. Yancopoulos +7 more
TL;DR: The ciliary neurotrophic factor receptor complex is shown here to include the CNTF binding protein (CNTFR alpha) as well as the components of the leukemia inhibitory factor (LIF) receptor, LIFR beta (the LIF binding protein) and gp130 [the signal transducer of interleukin-6 (IL-6)].