H
Harald Mikkers
Researcher at Leiden University Medical Center
Publications - 41
Citations - 1679
Harald Mikkers is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 16, co-authored 39 publications receiving 1478 citations. Previous affiliations of Harald Mikkers include Netherlands Cancer Institute.
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Journal ArticleDOI
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer
Harald Mikkers,John F. Allen,Puck Knipscheer,Lieke Romeyn,Augustinus A. M. Hart,Edwin Vink,Anton Berns +6 more
TL;DR: An in vivo mammalian genetic screen used to identify components of pathways contributing to oncogenic transformation is described and it is found that Pim3 is selectively activated in Pim-null tumor cells, which supports the validity of the approach.
Journal ArticleDOI
Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors
Harald Mikkers,Martijn C. Nawijn,John F. Allen,Conny Brouwers,Els Verhoeven,Jos Jonkers,Anton Berns +6 more
TL;DR: It is indicated that members of the PIM family of proteins are important but dispensable factors for growth factor signaling.
Book ChapterDOI
Retroviral insertional mutagenesis: tagging cancer pathways.
Harald Mikkers,Anton Berns +1 more
TL;DR: Novel advances, such as the launch of the complete mouse genome, high-throughput isolation of proviral flanking sequences, and genetically modified animals have revolutionized proviral tagging into an elegant and efficient approach to identify signaling pathways that collaborate in cancer.
Journal ArticleDOI
Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP
Uwe Konietzko,Gunther Kauselmann,Joey Scafidi,Ursula Staubli,Harald Mikkers,Anton Berns,Michaela Schweizer,Robert Waltereit,Dietmar Kuhl +8 more
TL;DR: Pim‐1, a serine/threonine kinase closely related to Pim‐2 and Pim-3, is induced in hippocampus in response to stimuli that evoke long‐term potentiation (LTP) and its level of expression might be a determining factor for the establishment of long‐lasting changes in synaptic strength.
Journal ArticleDOI
Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation
Fanie Barnabé-Heider,Konstantinos Meletis,Malin Eriksson,Olaf Bergmann,Hanna Sabelström,Michael A. Harvey,Harald Mikkers,Jonas Frisén +7 more
TL;DR: This work devised a rapid strategy that allows localized in vivo transfection of plasmid DNA within the adult neurogenic niches without detectable brain damage and identified an essential role for cadherins in maintaining the integrity of the lateral ventricle wall.