H
Harnish Mukesh Naik
Researcher at Johns Hopkins University
Publications - 9
Citations - 599
Harnish Mukesh Naik is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Chinese hamster ovary cell & Medicine. The author has an hindex of 5, co-authored 6 publications receiving 329 citations.
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Journal ArticleDOI
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.
Sabra L. Klein,Andrew Pekosz,Han-Sol Park,Rebecca L. Ursin,Janna R. Shapiro,Sarah E. Benner,Kirsten Littlefield,Swetha Kumar,Harnish Mukesh Naik,Michael J. Betenbaugh,Ruchee Shrestha,Annie A. Wu,Robert M. Hughes,Imani Burgess,Patricio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Thomas C. Quinn,Thomas C. Quinn,David Sullivan,Shmuel Shoham,Andrew D. Redd,Andrew D. Redd,Evan M. Bloch,Arturo Casadevall,Aaron A.R. Tobian +25 more
TL;DR: Male sex, older age, and hospitalization with COVID-19 were associated with increased antibody responses across the serological assays, and IgG titers were greater than either IgM or IgA for S1, full length S, and S-RBD in the overall population.
Posted ContentDOI
Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.
Sabra L. Klein,Andrew Pekosz,Han-Sol Park,Rebecca L. Ursin,Janna R. Shapiro,Sarah E. Benner,Kirsten Littlefield,Swetha Kumar,Harnish Mukesh Naik,Michael J. Betenbaugh,Ruchee Shrestha,Annie A. Wu,Robert M. Hughes,Imani Burgess,Patricio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Thomas C. Quinn,Thomas C. Quinn,David Sullivan,Shmuel Shoham,Andrew D. Redd,Andrew D. Redd,Evan M. Bloch,Arturo Casadevall,Aaron A.R. Tobian +25 more
TL;DR: There was substantial heterogeneity in the antibody response among potential convalescent plasma donors, but sex, age and hospitalization emerged as factors that can be used to identify individuals with a high likelihood of having strong antiviral antibody levels.
Journal ArticleDOI
Recombinant Antibody Production in CHO and NS0 Cells: Differences and Similarities
TL;DR: Understanding genomic and metabolic differences between the two cell hosts from an ‘omics perspective has created a reference for media composition and antibody quality improvements.
Journal ArticleDOI
An unconventional uptake rate objective function approach enhances applicability of genome-scale models for mammalian cells.
Yiqun Chen,Brian O. McConnell,Venkata Gayatri Dhara,Harnish Mukesh Naik,Chien-Ting Li,Maciek R. Antoniewicz,Michael J. Betenbaugh +6 more
TL;DR: The unconventional uptake-rate objective functions (UOFs) approach is able to distinguish metabolic differences between three distinct CHO cell lines not directly observed using the conventional biomass growth maximization solutions and managed to identify the correct cell line from metabolic flux data.
Journal ArticleDOI
Impact of nucleotide sugar metabolism on protein N-glycosylation in Chinese Hamster Ovary (CHO) cell culture
TL;DR: A better understanding of nucleotide sugar profiles, coupled with glycosylation enzyme mechanisms, will help to elucidate what glycoengineering tools are needed to more effectively control and predict protein gly cosylation.