M
Michael J. Betenbaugh
Researcher at Johns Hopkins University
Publications - 316
Citations - 14475
Michael J. Betenbaugh is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Chinese hamster ovary cell & Cell culture. The author has an hindex of 61, co-authored 290 publications receiving 12352 citations. Previous affiliations of Michael J. Betenbaugh include University of Delaware & Johns Hopkins University School of Medicine.
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The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
Xun Xu,Harish Nagarajan,Nathan E. Lewis,Shengkai Pan,Zhiming Cai,Xin Liu,Wenbin Chen,Min Xie,Wenliang Wang,Stephanie Hammond,Mikael Rørdam Andersen,Norma F. Neff,Benedetto Passarelli,Winston Koh,H. Christina Fan,Jianbin Wang,Yaoting Gui,Kelvin H. Lee,Michael J. Betenbaugh,Michael J. Betenbaugh,Stephen R. Quake,Iman Famili,Bernhard O. Palsson,Jun Wang +23 more
TL;DR: A draft genomic sequence of the CHO-K1 ancestral cell line is presented and it is discussed how the availability of this genome sequence may facilitate genome-scale science for the optimization of biopharmaceutical protein production.
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A green light for engineered algae: redirecting metabolism to fuel a biotechnology revolution
TL;DR: Ongoing advances in cultivation techniques coupled with genetic manipulation of crucial metabolic networks will further promote microalgae as an attractive platform for the production of numerous high-value compounds.
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Genomic landscapes of Chinese hamster ovary cell lines as revealed by the Cricetulus griseus draft genome
Nathan E. Lewis,Xin Liu,Yuxiang Li,Harish Nagarajan,George Yerganian,Edward J. O’Brien,Aarash Bordbar,Anne M Roth,Jeffrey Rosenbloom,Chao Bian,Min Xie,Wenbin Chen,Ning Li,Deniz Baycin-Hizal,Haythem Latif,Jochen Förster,Michael J. Betenbaugh,Iman Famili,Xun Xu,Jun Wang,Bernhard O. Palsson +20 more
TL;DR: This analysis identified hamster genes missing in different CHO cell lines, and detected >3.7 million single-nucleotide polymorphisms (SNPs), 551,240 indels and 7,063 copy number variations.
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Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population.
Sabra L. Klein,Andrew Pekosz,Han-Sol Park,Rebecca L. Ursin,Janna R. Shapiro,Sarah E. Benner,Kirsten Littlefield,Swetha Kumar,Harnish Mukesh Naik,Michael J. Betenbaugh,Ruchee Shrestha,Annie A. Wu,Robert M. Hughes,Imani Burgess,Patricio Caturegli,Oliver Laeyendecker,Oliver Laeyendecker,Thomas C. Quinn,Thomas C. Quinn,David Sullivan,Shmuel Shoham,Andrew D. Redd,Andrew D. Redd,Evan M. Bloch,Arturo Casadevall,Aaron A.R. Tobian +25 more
TL;DR: Male sex, older age, and hospitalization with COVID-19 were associated with increased antibody responses across the serological assays, and IgG titers were greater than either IgM or IgA for S1, full length S, and S-RBD in the overall population.
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The effect of mixotrophy on microalgal growth, lipid content, and expression levels of three pathway genes in Chlorella sorokiniana
Minxi Wan,Minxi Wan,Peng Liu,Jin-lan Xia,Jin-lan Xia,Julian N. Rosenberg,George A. Oyler,Michael J. Betenbaugh,Zhen-yuan Nie,Zhen-yuan Nie,Guanzhou Qiu,Guanzhou Qiu +11 more
TL;DR: In this paper, Nannochloropsis oculata CCMP 525, Dunaliella salina FACHB 435, and Chlorella sorokiniana CCTCC M209220 were compared in mixotrophic and photoautotrophic cultures in terms of growth rate, protein, and lipid content.