H
Harold C. Smith
Researcher at University of Rochester
Publications - 140
Citations - 5361
Harold C. Smith is an academic researcher from University of Rochester. The author has contributed to research in topics: RNA editing & RNA. The author has an hindex of 41, co-authored 140 publications receiving 5111 citations. Previous affiliations of Harold C. Smith include Baylor College of Medicine & State University of New York System.
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Messenger rna editing in mammals: new members of the apobec family seeking roles in the family business
TL;DR: Several proteins have been identified as being similar to C-to-U mRNA editing enzymes based on their structural domains and the occurrence of a catalytic domain characteristic of cytidine deaminases and their structure, expression and relevance to biomedically significant processes or pathologies are considered.
Journal ArticleDOI
The APOBEC Protein Family: United by Structure, Divergent in Function
TL;DR: This work has shown that loss of cellular control of APOBEC activities leads to DNA hypermutation and promiscuous RNA editing associated with the development of cancer or viral drug resistance, underscoring the importance of understanding how APOBec proteins are regulated.
Journal ArticleDOI
Functions and regulation of the APOBEC family of proteins.
TL;DR: APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in the APOBEC family to be functionally characterized as discussed by the authors, and under appropriate conditions it also deaminates deoxycytidine in single-stranded DNA.
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The Neurofibromatosis Type I Messenger RNA Undergoes Base-Modification RNA Editing
TL;DR: In vitro editing and transfection assays demonstrated that apoB and NF1 RNA editing will take place in both neural tumor and hepatoma cells, suggesting that different trans-acting factors may be involved in the two editing processes.