H
Harry L. Malech
Researcher at National Institutes of Health
Publications - 419
Citations - 30109
Harry L. Malech is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chronic granulomatous disease & Genetic enhancement. The author has an hindex of 86, co-authored 392 publications receiving 27644 citations. Previous affiliations of Harry L. Malech include University of Maryland, Baltimore & University of Connecticut.
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Journal ArticleDOI
Chronic granulomatous disease. Report on a national registry of 368 patients.
Jerry A. Winkelstein,Mary C. Marino,Richard B. Johnston,John Boyle,John T. Curnutte,John I. Gallin,Harry L. Malech,S.M. Holland,Hans D. Ochs,Paul G. Quie,Rebecca H. Buckley,Charles B. Foster,S. J. Chanock,Howard B. Dickler +13 more
TL;DR: A registry of United States residents with chronic granulomatous disease (CGD) was established in 1993 in order to estimate the minimum incidence of this uncommon primary immunodeficiency disease and characterize its epidemiologic and clinical features.
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STAT3 Mutations in the Hyper-IgE Syndrome
Steven M. Holland,Frank R. DeLeo,Houda Elloumi,Amy P. Hsu,Gulbu Uzel,Nina N. Brodsky,Alexandra F. Freeman,Andrew P. Demidowich,Joie Davis,Maria L. Turner,Victoria L. Anderson,Dirk Darnell,Pamela Welch,Douglas B. Kuhns,David M. Frucht,Harry L. Malech,John I. Gallin,Scott D. Kobayashi,Adeline R. Whitney,Jovanka M. Voyich,James M. Musser,Cristina Woellner,Alejandro A. Schäffer,Jennifer M. Puck,Bodo Grimbacher +24 more
TL;DR: Mutations in STAT3 underlie sporadic and dominant forms of the hyper-IgE syndrome, an immunodeficiency syndrome involving increased innate immune response, recurrent infections, and complex somatic features.
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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
Christian Lood,Luz P. Blanco,Monica M. Purmalek,Carmelo Carmona-Rivera,Suk See De Ravin,Carolyne K. Smith,Harry L. Malech,Jeffrey A. Ledbetter,Keith B. Elkon,Mariana J. Kaplan +9 more
TL;DR: Findings highlight a role for mitochondria in the generation not only of NETs but also of pro-inflammatory oxidized mitochondrial DNA in autoimmune diseases.
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Current concepts: immunology; neutrophils in human diseases
Harry L. Malech,John I. Gallin +1 more
TL;DR: HUMAN neutrophilic polymorphonuclear leukocytes (neutrophils) provide an effective host defense against bacterial and fungal infection, but they are also important in the pathogenesis of tissue damage in certain noninfectious diseases.
Journal ArticleDOI
Genetic, biochemical, and clinical features of chronic granulomatous disease
TL;DR: The reduced nicotinamide dinucleotide phosphate (NADPH) oxidase complex allows phagocytes to rapidly convert O2 to superoxide anion which then generates other antimicrobial reactive oxygen intermediates, such as H2O2, hydroxyl anion, and peroxynitrite anion.