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Andrew P. Demidowich
Researcher at National Institutes of Health
Publications - 66
Citations - 2178
Andrew P. Demidowich is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Insulin resistance. The author has an hindex of 17, co-authored 54 publications receiving 1768 citations. Previous affiliations of Andrew P. Demidowich include Johns Hopkins University & Howard County General Hospital.
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Journal ArticleDOI
STAT3 Mutations in the Hyper-IgE Syndrome
Steven M. Holland,Frank R. DeLeo,Houda Elloumi,Amy P. Hsu,Gulbu Uzel,Nina N. Brodsky,Alexandra F. Freeman,Andrew P. Demidowich,Joie Davis,Maria L. Turner,Victoria L. Anderson,Dirk Darnell,Pamela Welch,Douglas B. Kuhns,David M. Frucht,Harry L. Malech,John I. Gallin,Scott D. Kobayashi,Adeline R. Whitney,Jovanka M. Voyich,James M. Musser,Cristina Woellner,Alejandro A. Schäffer,Jennifer M. Puck,Bodo Grimbacher +24 more
TL;DR: Mutations in STAT3 underlie sporadic and dominant forms of the hyper-IgE syndrome, an immunodeficiency syndrome involving increased innate immune response, recurrent infections, and complex somatic features.
Journal ArticleDOI
Brief report: genotype, phenotype, and clinical course in five patients with PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, and acne).
Andrew P. Demidowich,Alexandra F. Freeman,Douglas B. Kuhns,Ivona Aksentijevich,John I. Gallin,Maria L. Turner,Daniel L. Kastner,Steven M. Holland +7 more
TL;DR: It is demonstrated that mutations in PSTPIP1 are incompletely penetrant and variably expressed in the PAPA syndrome, and Neutrophil granule proteins are markedly elevated ex vivo and in the plasma, and elevated levels might be compatible with a diagnosis of PAPa syndrome.
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Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.
Kazutaka Nanba,Kei Omata,Celso E. Gomez-Sanchez,Celso E. Gomez-Sanchez,Constantine A. Stratakis,Andrew P. Demidowich,Mari Suzuki,Lester D.R. Thompson,Debbie L. Cohen,James M. Luther,Lan L. Gellert,Anand Vaidya,Justine A. Barletta,Tobias Else,Thomas J. Giordano,Scott A. Tomlins,William E. Rainey +16 more
TL;DR: Determination of racial differences in the prevalence of aldosterone-driver gene mutations may facilitate the development of personalized medicines for patients with primary aldosteronism, and unlike Europeans and East Asians, the most frequently mutated ald testosterone-drivers gene was CACNA1D.
Journal ArticleDOI
Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus
Zongyang Mou,Thomas M. Hyde,Barbara K. Lipska,Keri Martinowich,Peter Wei,Peter Wei,Chiew Jen Ong,Chiew Jen Ong,Lindsay A. Hunter,Lindsay A. Hunter,Gladys I. Palaguachi,Gladys I. Palaguachi,Eva Morgun,Rujia Teng,Chen Lai,Chen Lai,Tania Condarco,Andrew P. Demidowich,Amanda J. Krause,Leslie J. Marshall,Karin Haack,V. Saroja Voruganti,V. Saroja Voruganti,Shelley A. Cole,Nancy F. Butte,Anthony G. Comuzzie,Mike A. Nalls,Alan B. Zonderman,Andrew B. Singleton,Michele K. Evans,Bronwen Martin,Stuart Maudsley,Jack W. Tsao,Jack W. Tsao,Jack W. Tsao,Joel E. Kleinman,Jack A. Yanovski,Joan C. Han +37 more
TL;DR: Findings provide a rationale for BDNF augmentation as a targeted treatment for obesity in individuals who have the rs12291063 CC genotype.
Journal ArticleDOI
Colchicine to decrease NLRP3-activated inflammation and improve obesity-related metabolic dysregulation.
TL;DR: It is hypothesized that, in at-risk individuals (those with obesity-induced inflammation and metabolic dysregulation), long-term colchicine use will lead to suppression of inflammation and thus cause improvements in insulin sensitivity and other obesity-related metabolic impairments.