H
Harry Martin
Researcher at Plant & Food Research
Publications - 29
Citations - 1209
Harry Martin is an academic researcher from Plant & Food Research. The author has contributed to research in topics: Gene isoform & Protein kinase C. The author has an hindex of 17, co-authored 29 publications receiving 1145 citations. Previous affiliations of Harry Martin include National Institute for Medical Research & HortResearch.
Papers
More filters
Journal ArticleDOI
Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components.
TL;DR: The high and increasing incidence of inflammatory and allergic disease, coupled with encouraging results from recent clinical trials, suggest that natural PPARγ agonists found in foods may be beneficial to human health by acting as anti-inflammatory molecules.
Journal ArticleDOI
Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies.
TL;DR: The finding that the 14‐3‐3 proteins are associated with different populations of synaptic membranes suggests that they are selectively expressed in different classes of neurones and raises the possibility that some or all of them may influence neurotransmission by regulating exocytosis and/or phosphorylation.
Journal ArticleDOI
Expression and structural analysis of 14-3-3 proteins.
David H. Jones,Harry Martin,Joel Madrazo,Karen Robinson,Peter Nielsen,Patrick H. Roseboom,Yasmina Patel,Steven Howell,Alastair Aitken +8 more
TL;DR: Protease digestion of intact 14-3-3 showed that the N-terminal half of 14- 3-3 was an intact, dimeric domain of the protein, which may imply that the proteins may adopt a different structural conformation, possibly upon binding to the membrane, which could modulate their activity.
Journal ArticleDOI
Antibodies against the major brain isoforms of 14-3-3 protein: an antibody specific for the N-acetylated amino-terminus of a protein.
TL;DR: Specific antibodies against each mammalian brain isoform of 14-3-3 employing peptides synthesised from the amino-terminal regions were raised, like the proteins from mammalian brain, N-acetylated.
Journal ArticleDOI
Mechanism of inhibition of protein kinase C by 14-3-3 isoforms. 14-3-3 isoforms do not have phospholipase A2 activity.
Karen Robinson,David T. Jones,Yasmina Patel,Harry Martin,Joel Madrazo,Sheree Martin,Steven Howell,M Elmore,MJ Finnen,Alastair Aitken +9 more
TL;DR: The ability of individual members of the 14-3-3 protein family to inhibit protein kinase C (PKC) has been studied by using a synthetic peptide based on the specific 80 kDa substrate for PKC in two different assay systems, and no PLA2 activity was found in brain 14- 3-3, nor in any of the recombinant proteins tested.