H
Harsha Doddapaneni
Researcher at Baylor College of Medicine
Publications - 4
Citations - 578
Harsha Doddapaneni is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Exome & Exome sequencing. The author has an hindex of 4, co-authored 4 publications receiving 457 citations. Previous affiliations of Harsha Doddapaneni include Baylor University.
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Additional file 11: Table S8. of Structure and function of the healthy pre-adolescent pediatric gut microbiome
Emily B. Hollister,Kevin Riehle,Ruth Ann Luna,Erica M. Weidler,Michelle Rubio-Gonzales,Toni-Ann Mistretta,Sabeen Raza,Harsha Doddapaneni,Ginger A. Metcalf,Donna Muzny,R. A. Gibbs,Joseph Petrosino,Robert J. Shulman,James Versalovic +13 more
Journal ArticleDOI
Lessons learned from additional research analyses of unsolved clinical exome cases
Mohammad K. Eldomery,Mohammad K. Eldomery,Zeynep H. Coban-Akdemir,Tamar Harel,Jill A. Rosenfeld,Tomasz Gambin,Tomasz Gambin,Asbjørg Stray-Pedersen,Sébastien Küry,Sandra Mercier,Davor Lessel,Jonas Denecke,Wojciech Wiszniewski,Wojciech Wiszniewski,Samantha Penney,Pengfei Liu,Weimin Bi,Seema R. Lalani,Seema R. Lalani,Christian P. Schaaf,Christian P. Schaaf,Michael F. Wangler,Michael F. Wangler,Carlos A. Bacino,Carlos A. Bacino,Richard Alan Lewis,Richard Alan Lewis,Lorraine Potocki,Lorraine Potocki,Brett H. Graham,Brett H. Graham,John W. Belmont,John W. Belmont,Fernando Scaglia,Fernando Scaglia,Jordan S. Orange,Jordan S. Orange,Shalini N. Jhangiani,Theodore Chiang,Harsha Doddapaneni,Jianhong Hu,Donna M. Muzny,Fan Xia,Arthur L. Beaudet,Eric Boerwinkle,Eric Boerwinkle,Christine M. Eng,Sharon E. Plon,V. Reid Sutton,V. Reid Sutton,Richard A. Gibbs,Richard A. Gibbs,Jennifer E. Posey,Yaping Yang,James R. Lupski +54 more
TL;DR: In this article, the authors designed and implemented protocols for the study of cases for which a plausible molecular diagnosis was not achieved in a clinical genomics diagnostic laboratory (i.e., unsolved clinical exomes).
Lessons learned from additional research analyses of unsolved clinical exome cases
Mohammad K. Eldomery,Mohammad K. Eldomery,Zeynep H. Coban-Akdemir,Tamar Harel,Jill A. Rosenfeld,Tomasz Gambin,Tomasz Gambin,Asbjørg Stray-Pedersen,Sébastien Küry,Sandra Mercier,Davor Lessel,Jonas Denecke,Wojciech Wiszniewski,Wojciech Wiszniewski,Samantha Penney,Pengfei Liu,Weimin Bi,Seema R. Lalani,Seema R. Lalani,Christian P. Schaaf,Christian P. Schaaf,Michael F. Wangler,Michael F. Wangler,Carlos A. Bacino,Carlos A. Bacino,Richard Alan Lewis,Richard Alan Lewis,Lorraine Potocki,Lorraine Potocki,Brett H. Graham,Brett H. Graham,John W. Belmont,John W. Belmont,Fernando Scaglia,Fernando Scaglia,Jordan S. Orange,Jordan S. Orange,Shalini N. Jhangiani,Theodore Chiang,Harsha Doddapaneni,Jianhong Hu,Donna M. Muzny,Fan Xia,Arthur L. Beaudet,Eric Boerwinkle,Eric Boerwinkle,Christine M. Eng,Sharon E. Plon,V. Reid Sutton,V. Reid Sutton,Richard A. Gibbs,Richard A. Gibbs,Jennifer E. Posey,Yaping Yang,James R. Lupski +54 more
TL;DR: An efficient genomics pipeline in which clinical sequencing in a diagnostic laboratory is followed by the detailed reanalysis of unsolved cases in a research environment, supplemented with WES data from additional family members, and subject to adjuvant bioinformatics analyses including relaxed variant filtering parameters in informatics pipelines, can enhance the molecular diagnostic yield and provide mechanistic insights into Mendelian disorders.
Journal ArticleDOI
Exome sequencing in mostly consanguineous Arab families with neurologic disease provides a high potential molecular diagnosis rate
Wu Lin Charng,Wu Lin Charng,Ender Karaca,Ender Karaca,Zeynep Coban Akdemir,Zeynep Coban Akdemir,Tomasz Gambin,Tomasz Gambin,Mehmed M. Atik,Mehmed M. Atik,Shen Gu,Shen Gu,Jennifer E. Posey,Jennifer E. Posey,Shalini N. Jhangiani,Shalini N. Jhangiani,Donna Muzny,Donna Muzny,Harsha Doddapaneni,Harsha Doddapaneni,Jianhong Hu,Jianhong Hu,Eric Boerwinkle,Eric Boerwinkle,Richard A. Gibbs,Richard A. Gibbs,Jill A. Rosenfeld,Jill A. Rosenfeld,Hong Cui,Hong Cui,Fan Xia,Fan Xia,Kandamurugu Manickam,Yaping Yang,Yaping Yang,Eissa Faqeih,Ali Al Asmari,Mohammed A. Saleh,Ayman W. El-Hattab,James R. Lupski +39 more
TL;DR: In this paper, the authors applied whole exome sequencing (WES) for molecular diagnosis and in silico analysis to identify novel disease gene candidates in a cohort from Saudi Arabia with primarily Mendelian neurologic diseases.