D
Davor Lessel
Researcher at University of Hamburg
Publications - 84
Citations - 3243
Davor Lessel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Medicine & Missense mutation. The author has an hindex of 23, co-authored 69 publications receiving 2011 citations. Previous affiliations of Davor Lessel include University of Ulm.
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Journal ArticleDOI
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Fredrick R. Schumacher,Ali Amin Al Olama,Sonja I. Berndt,Sara Benlloch,Mahbubl Ahmed,Edward J. Saunders,Tokhir Dadaev,Daniel Leongamornlert,Ezequiel Anokian,Clara Cieza-Borrella,Chee Goh,Mark N. Brook,Xin Sheng,Laura Fachal,Joe Dennis,Jonathan Tyrer,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Artitaya Lophatananon,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Jyotsna Batra,Jyotsna Batra,Suzanne K. Chambers,Suzanne K. Chambers,Leire Moya,Leire Moya,Judith A. Clements,Judith A. Clements,Lisa G. Horvath,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Tobias Nordström,Paul D.P. Pharoah,Nora Pashayan,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Demetrius Albanes,Stephanie J. Weinstein,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Catharine M L West,Alison M. Dunning,Neil G. Burnet,Lorelei A. Mucci,Edward Giovannucci,Gerald L. Andriole,Olivier Cussenot,Geraldine Cancel-Tassin,Stella Koutros,Laura E. Beane Freeman,Karina Dalsgaard Sørensen,Torben F. Ørntoft,Michael Borre,Lovise Maehle,Eli Marie Grindedal,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Ruth C. Travis,Timothy J. Key,Robert J. Hamilton,Neil E. Fleshner,Antonio Finelli,Sue A. Ingles,Mariana C. Stern,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Xin Guo,Guomin Wang,Zan Sun,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Liesel M. FitzGerald,Liesel M. FitzGerald,Adam S. Kibel,Bettina F. Drake,Ana Vega,Antonio Gómez-Caamaño,Robert Szulkin,Martin Eklund,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Kathryn L. Penney,Meir J. Stampfer,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Janet L. Stanford,Janet L. Stanford,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,Elaine A. Ostrander,Milan S. Geybels,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Rasmus Bisbjerg,Martin Andreas Røder,Peter Iversen,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Christiane Maier,Manuel Luedeke,Thomas J. Schnoeller,Jeri Kim,Christopher J. Logothetis,Esther M. John,Esther M. John,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Marta Cardoso,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,Kim De Ruyck,Gert De Meerleer,Piet Ost,Azad Hassan Abdul Razack,Jasmine Lim,Soo Hwang Teo,Daniel W. Lin,Daniel W. Lin,Lisa F. Newcomb,Lisa F. Newcomb,Davor Lessel,Marija Gamulin,Tomislav Kuliš,Radka Kaneva,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Sandeep Singhal,Chavdar Slavov,Vanio Mitev,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Samantha E.T. Larkin,Paul A. Townsend,Claire Aukim-Hastie,Manuela Gago Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Jianfeng Xu,Kay-Tee Khaw,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hardev Pandha,Agnieszka Michael,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Sara Lindström,Constance Turman,Jing Ma,David J. Hunter,Elio Riboli,A. Siddiq,Federico Canzian,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Zuxi Cui,Peter Kraft,Christopher I. Amos,David V. Conti,Douglas F. Easton,Fredrik Wiklund,Stephen J. Chanock,Brian E. Henderson,Zsofia Kote-Jarai,Christopher A. Haiman,Rosalind A. Eeles +207 more
TL;DR: A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.
Journal ArticleDOI
Integrated Molecular Characterization of Testicular Germ Cell Tumors
Hui Shen,Juliann Shih,Daniel P. Hollern,Linghua Wang,Reanne Bowlby,Satish K. Tickoo,Vesteinn Thorsson,Andrew J. Mungall,Yulia Newton,Apurva M. Hegde,Joshua Armenia,Francisco Sanchez-Vega,John Pluta,Louise C. Pyle,Rohit Mehra,Victor E. Reuter,Guilherme Godoy,Jeffrey A. Jones,Carl Simon Shelley,Darren R. Feldman,Daniel Onofre Vidal,Davor Lessel,Tomislav Kuliš,Flavio Mavignier Carcano,Kristen M. Leraas,Tara M. Lichtenberg,Denise Brooks,Andrew D. Cherniack,Juok Cho,David I. Heiman,Katayoon Kasaian,Minwei Liu,Michael S. Noble,Liu Xi,Hailei Zhang,Wanding Zhou,Jean C. Zenklusen,Carolyn M. Hutter,Ina Felau,Jiashan Zhang,Nikolaus Schultz,Gad Getz,Matthew Meyerson,Joshua M. Stuart,Rehan Akbani,David A. Wheeler,Peter W. Laird,Katherine L. Nathanson,Victoria K. Cortessis,Katherine A. Hoadley +49 more
TL;DR: High-dimensional analyses identified distinct molecular patterns that characterized the major recognized histologic subtypes of TGCT: seminoma, embryonal carcinoma, yolk sac tumor, and teratoma, and a subset of pure seminomas defined by KIT mutations, increased immune infiltration, globally demethylated DNA, and decreased KRAS copy number.
Journal ArticleDOI
Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
David V. Conti,Burcu F. Darst,Lilit C. Moss,Edward J. Saunders,Xin Sheng,Alisha Chou,Fredrick R. Schumacher,Ali Amin Al Olama,Sara Benlloch,Tokhir Dadaev,Mark N. Brook,Ali Sahimi,Thomas J. Hoffmann,Atushi Takahashi,Koichi Matsuda,Yukihide Momozawa,Masashi Fujita,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Peggy Wan,Loic Le Marchand,Lynne R. Wilkens,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Graham G. Giles,Graham G. Giles,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Stig E. Bojesen,Martin Andreas Røder,Peter Iversen,Jyotsna Batra,Suzanne K. Chambers,Leire Moya,Lisa G. Horvath,Judith A. Clements,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Robert Szulkin,Martin Eklund,Tobias Nordström,Nora Pashayan,Alison M. Dunning,Maya Ghoussaini,Ruth C. Travis,Timothy J. Key,Elio Riboli,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Demetrius Albanes,Stephanie J. Weinstein,Lorelei A. Mucci,Edward Giovannucci,Sara Lindström,Peter Kraft,David J. Hunter,Kathryn L. Penney,Constance Turman,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Robert J. Hamilton,Robert J. Hamilton,Neil Fleshner,Antonio Finelli,Marie-Élise Parent,Marie-Élise Parent,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Milan S. Geybels,Stella Koutros,Laura E. Beane Freeman,Meir J. Stampfer,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Gerald L. Andriole,Robert N. Hoover,Mitchell J. Machiela,Karina Dalsgaard Sørensen,Michael Borre,William J. Blot,Wei Zheng,Edward D. Yeboah,Edward D. Yeboah,James E. Mensah,James E. Mensah,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Yudong Wu,Shan Chao Zhao,Zan Sun,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Catharine M L West,Neil G. Burnet,Gill Barnett,Christiane Maier,Thomas J. Schnoeller,Manuel Luedeke,Adam S. Kibel,Bettina F. Drake,Olivier Cussenot,Geraldine Cancel-Tassin,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Esther M. John,Eli Marie Grindedal,Lovise Maehle,Kay-Tee Khaw,Sue A. Ingles,Mariana C. Stern,Ana Vega,Antonio Gómez-Caamaño,Laura Fachal,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Andreia Brandão,Stephen Watya,Alexander Lubwama,Jeannette T. Bensen,Elizabeth T. H. Fontham,James L. Mohler,James L. Mohler,Jack A. Taylor,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Craig C. Teerlink,Craig C. Teerlink,Chad D. Huff,Sara S. Strom,Luc Multigner,Pascal Blanchet,Laurent Brureau,Radka Kaneva,Chavdar Slavov,Vanio Mitev,Robin J. Leach,Brandi Weaver,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Kai Uwe Saum,Eric A. Klein,Ann W. Hsing,Rick A. Kittles,Adam B. Murphy,Christopher J. Logothetis,Jeri Kim,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,William B. Isaacs,Barbara Nemesure,Anselm Hennis,Anselm Hennis,John D. Carpten,Hardev Pandha,Agnieszka Michael,Kim De Ruyck,Gert De Meerleer,Piet Ost,Jianfeng Xu,Azad Hassan Abdul Razack,Jasmine Lim,Soo-Hwang Teo,Lisa F. Newcomb,Daniel W. Lin,Jay H. Fowke,Christine Neslund-Dudas,Benjamin A. Rybicki,Marija Gamulin,Davor Lessel,Tomislav Kuliš,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Manuela Gago-Dominguez,Manuela Gago-Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Samantha E.T. Larkin,Paul A. Townsend,Paul A. Townsend,Claire Aukim-Hastie,William S. Bush,Melinda C. Aldrich,Dana C. Crawford,Shiv Srivastava,Jennifer Cullen,Gyorgy Petrovics,Graham Casey,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Jennifer J. Hu,Maureen Sanderson,Rohit Varma,Roberta McKean-Cowdin,Mina Torres,Nicholas Mancuso,Sonja I. Berndt,Stephen K. Van Den Eeden,Stephen K. Van Den Eeden,Douglas F. Easton,Stephen J. Chanock,Michael B. Cook,Fredrik Wiklund,Hidewaki Nakagawa,John S. Witte,Rosalind A. Eeles,Rosalind A. Eeles,Zsofia Kote-Jarai,Christopher A. Haiman +254 more
TL;DR: This paper conducted a meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants.
Journal ArticleDOI
Lessons learned from additional research analyses of unsolved clinical exome cases
Mohammad K. Eldomery,Mohammad K. Eldomery,Zeynep H. Coban-Akdemir,Tamar Harel,Jill A. Rosenfeld,Tomasz Gambin,Tomasz Gambin,Asbjørg Stray-Pedersen,Sébastien Küry,Sandra Mercier,Davor Lessel,Jonas Denecke,Wojciech Wiszniewski,Wojciech Wiszniewski,Samantha Penney,Pengfei Liu,Weimin Bi,Seema R. Lalani,Seema R. Lalani,Christian P. Schaaf,Christian P. Schaaf,Michael F. Wangler,Michael F. Wangler,Carlos A. Bacino,Carlos A. Bacino,Richard Alan Lewis,Richard Alan Lewis,Lorraine Potocki,Lorraine Potocki,Brett H. Graham,Brett H. Graham,John W. Belmont,John W. Belmont,Fernando Scaglia,Fernando Scaglia,Jordan S. Orange,Jordan S. Orange,Shalini N. Jhangiani,Theodore Chiang,Harsha Doddapaneni,Jianhong Hu,Donna M. Muzny,Fan Xia,Arthur L. Beaudet,Eric Boerwinkle,Eric Boerwinkle,Christine M. Eng,Sharon E. Plon,V. Reid Sutton,V. Reid Sutton,Richard A. Gibbs,Richard A. Gibbs,Jennifer E. Posey,Yaping Yang,James R. Lupski +54 more
TL;DR: In this article, the authors designed and implemented protocols for the study of cases for which a plausible molecular diagnosis was not achieved in a clinical genomics diagnostic laboratory (i.e., unsolved clinical exomes).
Journal ArticleDOI
Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features
Davor Lessel,Davor Lessel,Bruno Vaz,Swagata Halder,Swagata Halder,Paul J. Lockhart,Ivana Marinović-Terzić,Jaime Lopez-Mosqueda,Melanie Philipp,Joe C H Sim,Katherine R. Smith,Katherine R. Smith,Judith Oehler,Judith Oehler,Elisa Cabrera,Raimundo Freire,Kate Pope,Amsha Nahid,Fiona Norris,Richard J. Leventer,Richard J. Leventer,Martin B. Delatycki,Gotthold Barbi,Simon von Ameln,Josef Högel,Marina Degoricija,Regina Fertig,Martin D. Burkhalter,Kay Hofmann,Holger Thiele,Janine Altmüller,Gudrun Nürnberg,Peter Nürnberg,Melanie Bahlo,Melanie Bahlo,George M. Martin,Cora M. Aalfs,Junko Oshima,Janoš Terzić,David J. Amor,Ivan Dikic,Kristijan Ramadan,Kristijan Ramadan,Christian Kubisch,Christian Kubisch +44 more
TL;DR: In vivo and in vitro characterization of identified mutations in SPRTN has uncovered an essential role for SPRTN in the prevention of DNA replication stress during general DNA replication and in replication-related G2/M-checkpoint regulation.