H
Harshit Shah
Researcher at North Dakota State University
Publications - 10
Citations - 73
Harshit Shah is an academic researcher from North Dakota State University. The author has contributed to research in topics: Cancer cell & Cancer. The author has an hindex of 4, co-authored 8 publications receiving 37 citations.
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Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression
TL;DR: The 3WJ RNA nanoparticle system holds great promise as a suitable therapeutic delivery platform for colon cancer therapy and was confirmed that 8-HOA formation, promoted by COX-2-catalyzed DGLA peroxidation, inhibited HDAC and consequently induced apoptosis in tumor cells.
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EpCAM-Targeted 3WJ RNA Nanoparticle Harboring Delta-5-Desaturase siRNA Inhibited Lung Tumor Formation via DGLA Peroxidation.
TL;DR: 3WJ-RNA nanoparticle could improve the targeting and effectiveness of D5D siRNA in lung cancer therapy by promoting the 8-HOA formation from the COX-2-catalyzed DGLA peroxidation, which inhibited lung cancer growth in vivo and in vitro.
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Growth inhibitory and anti-metastatic activity of epithelial cell adhesion molecule targeted three-way junctional delta-5-desaturase siRNA nanoparticle for breast cancer therapy
TL;DR: A significant reduction in tumor size and metastatic lung nodules in animals treated with a combination of 3WJ-EpCAM-D5D siRNA and DGLA through activating intrinsic apoptotic signaling pathway and by reducing endothelial-mesenchymal damage is observed.
Journal ArticleDOI
In Vitro Photodynamic Therapy of Mononuclear and Dinuclear Iridium(III) Bis(terpyridine) Complexes
Cuifen Lu,Cuifen Lu,Wan Xu,Harshit Shah,Bingqing Liu,Wei Xu,Liya Sun,Steven Y. Qian,Wenfang Sun +8 more
TL;DR: In this paper, three mononuclear or dinuclear bis(terpyridine) (tpy) iridium(III) complexes bearing pyren-1-yl (pyr) group(s) were synthesized.
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Delta-5-desaturase: A novel therapeutic target for cancer management.
TL;DR: In this paper, the role of delta-5 desaturase (D5D) in cancer development is discussed. But, the mechanistic basis of D5D in cancer progression is still controversial.