Showing papers in "Nanomedicine: Nanotechnology, Biology and Medicine in 2020"

TL;DR: An overview of recent studies on the effectiveness of nanoparticles as diagnostic or antiviral tools against coronaviruses is provided and the possibilities of effectively using nanomaterials as vaccines and nanosensors in this field are presented.

TL;DR: The multiple applications and mechanisms of action of vitamin C will be reviewed and discussed, as well as the new possibilities of delivery and improvement of stability.

TL;DR: This review provides a comprehensive insight into the most recent advancements made in nanocarrier-based drug delivery to the CNS, such as the development of multifunctional nanomedicines and theranostics.

TL;DR: This novel approach directly leverages intact and natural functions of cell membranes, instead of replicating these features via synthetic techniques, to bestows NPs with enhanced biointerfacing capabilities with potential in the diagnosis and treatment of cancer, infection and other diseases.

TL;DR: The improved preclinical characterization of suitable siRNA drugs, good laboratory practice, that reduce the differences between in vitro and in vivo results may increase the success of si RNA drugs in clinical settings.

TL;DR: The objective of this review is to summarize the current development of novel active targeting liposomal formulations, and to give insight into the challenges and future direction of the field.

TL;DR: Rationally designed acid-activatable curcumin polymer (ACP), as a therapeutic prodrug ofCurcumin was covalently incorporated in the backbone of amphiphilic polymer, in which ACP could self-assemble to form micelles that rapidly release Curcumin under the acidic condition.

TL;DR: Interestingly, nanomedicine as a promising therapeutic approach could effectively help win the battle between coronaviruses (CoVs) and host cells, in the fields of vaccination, diagnosis and therapy.

TL;DR: Biosynthesized CeO2 NPs revealed multifunctional therapeutic properties and potent antimicrobial and antiviral properties with hemocompatibility were reported.

TL;DR: Recent advances in the development of drugs incorporated into PNPs are critically reviewed and the molecular changes and functional effects achieved in preclinical models of the most common ND disorders are summarized.

TL;DR: In this paper, a core-shell nanofibrous bioactive insulin-loaded poly-D-L-lactide-glycolide (PLGA) scaffolds were developed for repairing wounds in diabetic rats.

TL;DR: The biophysical properties of naturally-occurring and synthetic NPs, their pathological effects on the respiratory system and the potential human health risk are examined to provide the current evidence that exposure to NPs is a risk factor to develop human diseases.

TL;DR: A precisely designed sonodynamic chemotherapeutics which exhibits US-responsive drug release via ROS generation from co-loaded sono-sensitizer reveals potential as a multi-functional agent for sonodynamic chemotherapy.

TL;DR: Hollow OMVs were reinforced internally by size-controlled BSA nanoparticles to obtain uniform and stable vaccines through hydrophobic interaction and the structure optimization improved the immune efficacy of OMVs for vaccine development against CRKP.

TL;DR: The traditional treatment for bone infections has several drawbacks and limitations, such as lengthy antibiotic treatment, extensive surgical interventions, and removal of orthopaedic implants and/or prothesis, all of these resulting in long-term rehabilitation, which is a huge burden to the public health system resulting in increased healthcare costs.

TL;DR: Comparison temperature-dependent analysis of the cobalt ferrite nanoparticles-mediated MHT effectiveness in two murine tumors models shows high-temperature MHT resulted in complete 4 T1 primary tumor clearance, 25-40% long-term survival rates, and, importantly, more effective prevention of metastasis comparing to surgical extraction.

TL;DR: Elucidating the interface between nanoparticles and coronaviruses is timely, but presents the only route to the rational design of precisely targeted therapeutics for coronavirus infections.

TL;DR: Intranasal administration of nanoparticles carrying siRNA is a promising therapeutic alternative for safe and effective lowering of mutant HTT expression in Huntington's disease.

TL;DR: Quality-by-design approach has been applied to optimize lipid-based nanosystems formulations, including solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions, besides being increasingly requested by regulatory authorities.

TL;DR: An innovative delivery system based on bacteriophages-loaded alginate-nanohydroxyapatite hydrogel was developed as a multifunctional approach for local tissue regeneration and infection prevention and control and could be a promising approach to prevent and control bacterial contamination during implantation and bone integration.

TL;DR: An extensive study of various formulations both in vitro and in vivo reveals differences in their immunostimulatory activity, gene silencing efficiency, and biodistribution, with fibrous NANPs advancing for TNA delivery.

TL;DR: As a multifunctional nanoplatform integrating the PTT/PDT/CT strategies with tumor multimodal imaging or drug tracing, GNS@IR820/DTX-CD133 has the great potential for clinical applications in the antitumor therapy of CRPC.

TL;DR: ARV-NP showed significant cytotoxicity, apoptosis and anticlonogenic effect in pancreatic cancer cells, and significantly inhibited the cell viability of 3D tumor spheroids of pancreaticcancer.

TL;DR: Polymeric nanoparticles loaded with Zileuton™, a potent inhibitor of cancer stem cells (CSCs), reduce amount of CSCs within the tumor and effectively block the circulating tumor cells in the blood stream and metastatic spread.

TL;DR: Nanobubbles (NB) that specifically targets prostate specific membrane antigen (PSMA) overexpressed in PCa is reported that active targeting rapidly and selectively enhances tumor accumulation and tumor retention.

TL;DR: In this review, recent developments in the design and manufacturing of silver-based antibacterial surfaces are described in detail and based on current research in this promising field, the main challenges and perspectives for their effective implementation are discussed.

TL;DR: The exosome derived from KGN-preconditioned BMSCs (KGN-BMSC-Exos) performed more effectively than the exosomes derived from BMSC -Exos, and KGN preconditioning endowed B MSCs with stronger chondral matrix formation and less degradation.

TL;DR: Results indicate that SP1049C is active against cancer stem cells (CSCs) and has potential in treating TNBC.

TL;DR: The effect of carboplatin in a heterogeneity population of OVCA cells and their derived sEVs is studied to identify mechanisms associated with chemoresistance and the levels of miR-891-5p within s EVs is significantly higher in patients at risk of ovarian cancer relapse.