Delta-5-desaturase: A novel therapeutic target for cancer management.
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TLDR
In this paper, the role of delta-5 desaturase (D5D) in cancer development is discussed. But, the mechanistic basis of D5D in cancer progression is still controversial.About:
This article is published in Translational Oncology.The article was published on 2021-08-23 and is currently open access. It has received 5 citations till now. The article focuses on the topics: Cancer & Cancer cell.read more
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Futuristic food fortification with a balanced ratio of dietary ω-3/ω-6 omega fatty acids for the prevention of lifestyle diseases
Alok Kumar Patel,Sneha Desai,Varsha Kelkar Mane,Josefine Enman,Ulrika Rova,Paul Christakopoulos,Leonidas Matsakas +6 more
TL;DR: In this paper , the role of omega-3 and omega-6 fatty acids on human health is discussed and the latest developments regarding dietary sources, innovative technologies, and challenges of food fortification with ω-3 fatty acids are discussed.
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Recent status of sesaminol and its glucosides: Synthesis, metabolism, and biological activities.
Qi-zhang Li,Zan-Wen Zuo,Yan Lu +2 more
TL;DR: An overview of the current status of research on sesaminol and SGs can be found in this article , where the authors have also discussed their synthesis, preparation, metabolism, and biological activities.
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Dihomo-γ-Linolenic Acid (20:3n-6)—Metabolism, Derivatives, and Potential Significance in Chronic Inflammation
TL;DR: In this paper , the potential roles of DGLA and related n-6 PUFAs in inflammatory conditions, such as obesity-associated disorders, rheumatoid arthritis, atopic dermatitis, asthma, cancers, and diseases of the gastrointestinal tract, were examined.
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Lipases from different yeast strains: Production and application for n-3 fatty acid enrichment of tuna eyeball oil
TL;DR: In this paper , the authors used six extracellular and cell-bound lipases from three different yeast strains to enrich skipjack tuna eyeballs oil (STEO) with polyunsaturated fatty acids.
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Macronutrient Proportions and Fat Type Impact Ketogenicity and Shape the Circulating Lipidome in Dogs
TL;DR: It is demonstrated that the reduction of carbohydrate in canine foods is potentially beneficial to dogs based on improvements in metabolism and supports the use of low-carbohydrate foods as safe and effective for healthy adult dogs.
References
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
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The importance of the ratio of omega-6/omega-3 essential fatty acids.
TL;DR: In this article, a lower omega-6/omega-3 ratio in women with breast cancer was associated with decreased risk, whereas a higher ratio of omega-3 PUFA had no effect.
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Cardiovascular Risk Associated With Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention
Scott D. Solomon,John J.V. McMurray,Marc A. Pfeffer,Janet Wittes,Robert A. Fowler,Peter V. Finn,William F. Anderson,Ann G. Zauber,Ernest T. Hawk,Monica M. Bertagnolli +9 more
TL;DR: Celecoxib use was associated with a dose-related increase in the composite end point of death from cardiovascular causes, myocardial infarction, stroke, or heart failure, providing further evidence that the use of COX-2 inhibitors may increase the risk of serious cardiovascular events.
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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
José Pedro Friedmann Angeli,Manuela Schneider,Bettina Proneth,Yulia Y. Tyurina,Vladimir A. Tyurin,Victoria Jayne Hammond,Nadja Herbach,Michaela Aichler,Axel Walch,E. Eggenhofer,Devaraj Basavarajappa,Olof Rådmark,Sho Kobayashi,Tobias Seibt,Heike Beck,Frauke Neff,Irene Esposito,Rüdiger Wanke,Heidi Förster,Olena Yefremova,Marc Heinrichmeyer,Georg W. Bornkamm,Edward K. Geissler,Stephen B. Thomas,Brent R. Stockwell,Valerie B. O'Donnell,Valerian E. Kagan,Joel A. Schick,Marcus Conrad +28 more
TL;DR: It is demonstrated that ferroptosis is a pervasive and dynamic form of cell death, which, when impeded, promises substantial cytoprotection.
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ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung,Chang Bong Jun,Seung Hyun Ro,Young Mi Kim,Neil Michael Otto,Jing Cao,Mondira Kundu,Do Hyung Kim +7 more
TL;DR: It is identified that mTOR phosphorylates a mammalian homologue of Atg13 and the mammalian Atg1 homologues ULK1 and ULK2, which demonstrate that the ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in response to mTOR signaling.