H
Haruyo Nakajima-Adachi
Researcher at University of Tokyo
Publications - 33
Citations - 420
Haruyo Nakajima-Adachi is an academic researcher from University of Tokyo. The author has contributed to research in topics: Immune system & Ovalbumin. The author has an hindex of 11, co-authored 30 publications receiving 338 citations. Previous affiliations of Haruyo Nakajima-Adachi include Center for Food Safety & Children's Medical Center of Dallas.
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Journal ArticleDOI
Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine αs1-casein from the same patients allergic to cow's milk: Existence of αs1-casein–specific B cells and T cells characteristic in cow's-milk allergy
Haruyo Nakajima-Adachi,Satoshi Hachimura,Ise W,Honma K,Nishiwaki S,Hirota M,Naoki Shimojo,Toshiyuki Katsuki,Akio Ametani,Y. Kohno,Shuichi Kaminogawa +10 more
TL;DR: The results suggest that patients allergic to cow's milk have characteristic B cells recognizing a limited region ofalpha(s)1-casein and secreting alpha(s]1- casein-specific IgE, which may interact particularly with T cells recognizing determinants with a common structure.
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Mesenteric lymph node CD11b- CD103+ PD-L1High dendritic cells highly induce regulatory T cells.
TL;DR: Exogenous TGF‐β supplementation equalized the level of Foxp3+ T‐cell induction by the four subsets whereas retinoic acid did not, which suggests that high ability to activate TGF•β is determinant for the high Foxp2‐ T‐ cell induction by CD11b− CD103+ PD‐L1High DC subset.
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Food antigen causes TH2-dependent enteropathy followed by tissue repair in T-cell receptor transgenic mice.
Haruyo Nakajima-Adachi,Ayumi Ebihara,Akira Kikuchi,Tsuyoshi Ishida,Kiyomi Sasaki,K Hirano,Hiroko Watanabe,Kazumi Asai,Yoshimasa Takahashi,Yutaka Kanamori,Naoki Shimojo,Hiroshi Matsuda,Yoichi Kohno,Satoshi Hachimura,Shuichi Kaminogawa +14 more
TL;DR: It is reported that high-dose and continuous intake of primitive OVA alone induces enteropathy containing regions under repair in OVA23-3 mice, andAntigen-specific T cells and inflammatory cells primed by T(H)2 responses play important roles in regulation of development and improvement of the disease.
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Food allergens and mucosal immune systems with special reference to recognition of food allergens by gut-associated lymphoid tissue.
TL;DR: The process by which antigens or allergens are recognized by the GALT and the characteristic immune responses induced thereafter are described and the structure of T and B cell epitopes on food allergens will be discussed.
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Heat treatment of egg white controls allergic symptoms and induces oral tolerance to ovalbumin in a murine model of food allergy
Hiroko Watanabe,Masako Toda,Haruko Sekido,Anne Wellner,Tomoyuki Fujii,Thomas Henle,Satoshi Hachimura,Haruyo Nakajima-Adachi +7 more
TL;DR: Investigation of biochemical, allergenic, and tolerogenic properties of heated egg white (EW) using a murine model of food allergy finds OVA in EW treated only under a particular heat condition lost allergenicity, but possessed tolerogenicity.