H
Hatem A. Abdel-Aziz
Researcher at King Saud University
Publications - 249
Citations - 4788
Hatem A. Abdel-Aziz is an academic researcher from King Saud University. The author has contributed to research in topics: Ring (chemistry) & Pyrazole. The author has an hindex of 35, co-authored 227 publications receiving 3581 citations. Previous affiliations of Hatem A. Abdel-Aziz include Cairo University & Yahoo!.
Papers
More filters
Journal ArticleDOI
Synthesis and antimicrobial evaluation of 1-(benzofuran-2-yl)-4-nitro-3-arylbutan-1-ones and 3-(benzofuran-2-yl)-4,5-dihydro-5-aryl-1-[4-(aryl)-1,3-thiazol-2-yl]-1H-pyrazoles.
TL;DR: 2-Acetylbenzofuran 1 on treatment with substituted aldehydes affords the corresponding chalcones 2a-c, and pyrazolines 7a-d were synthesized by treating 4a,b with phenacyl bromides in refluxing ethanol.
Journal ArticleDOI
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies
Wagdy M. Eldehna,Mahmoud F. Abo-Ashour,Alessio Nocentini,Paola Gratteri,Ibrahim H. Eissa,Mohamed Fares,Omnia E Ismael,Hazem A. Ghabbour,Mahmoud M. Elaasser,Hatem A. Abdel-Aziz,Claudiu T. Supuran +10 more
TL;DR: The synthesis of two series of novel 4/3-((4-oxo-5-(2-oxOindolin-3-ylidene)thiazolidin-2-ylIDene)amino)benzenesulfonamides (4a-m and 7a-g) induced the intrinsic apoptotic mitochondrial pathway in MCF-7 cells; evidenced by the enhanced expression of the pro-apoptotic protein Bax and the reduced expression of
Journal ArticleDOI
Nanomolar Detection of Hypochlorite by a Rhodamine-Based Chiral Hydrazide in Absolute Aqueous Media: Application in Tap Water Analysis with Live-Cell Imaging
Shyamaprosad Goswami,Avijit Kumar Das,Abhishek Manna,Anup Kumar Maity,Partha Saha,Ching Kheng Quah,Hoong-Kun Fun,Hoong-Kun Fun,Hatem A. Abdel-Aziz +8 more
TL;DR: The sensibility of the receptor toward OCl(-) was studied in absolute aqueous media, and the detection limit of hypochlorite-mediated oxidation to the receptor in nanomolar level makes this platform (RHHP) an ultrasensitive and unique system for OCl (-) oxidation.
Journal ArticleDOI
Synthesis and antitumor activity of pyrido [2,3-d]pyrimidine and pyrido[2,3-d] [1,2,4]triazolo[4,3-a]pyrimidine derivatives that induce apoptosis through G1 cell-cycle arrest.
Mohamed Fares,Sahar M. Abou-Seri,Hatem A. Abdel-Aziz,Safinaz E. Abbas,Mohieldin M. Youssef,Mohieldin M. Youssef,Radwa A. Eladwy +6 more
TL;DR: The data indicated that 15f was able to cause cell cycle arrest at least partly through enhancing the expression level of the cell cycle inhibitor p21 and induced cancer cell apoptosis via caspase-3 dependent pathway.
Journal ArticleDOI
Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents.
TL;DR: A hybrid pharmacophore approach was adopted to design and synthesize new series of isatin-pyridine hybrids and the predicted activities by the QSAR model were very close to those experimentally observed, hinting that this model could be safely applied for prediction of more efficacious hits comprising the same skeletal framework.