Ibrahim H. Eissa

TL;DR: Interestingly, DNA binding assay results were in agreement with that of the cytotoxicity assays where the most potent anticancer compounds showed good DNA binding affinity comparable to that of doxorubicin and daunorubsicin.

TL;DR: The synthesis of two series of novel 4/3-((4-oxo-5-(2-oxOindolin-3-ylidene)thiazolidin-2-ylIDene)amino)benzenesulfonamides (4a-m and 7a-g) induced the intrinsic apoptotic mitochondrial pathway in MCF-7 cells; evidenced by the enhanced expression of the pro-apoptotic protein Bax and the reduced expression of

TL;DR: The synthesized thieno[2,3-d]pyrimidine derivatives as an EGFR and HER2 tyrosine kinase inhibitors and the results indicated that this compound arrests G2/M phase of the cell cycle and it is a good apoptotic agent.

TL;DR: Novel series of benzoxazoles 4a‐f‐16 was designed, synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 cells, finding compound 5e was found to be the most potent against hepatitis B cells with IC50 values of 5.93 ± 0.5 µM, respectively.

TL;DR: In vivo antitumor activities of the synthesized quinazoline-based derivatives revealed that compounds 30 and 31 possessed significant tumor growth inhibition effect, and it is said that VEGFR-2 inhibition confers the reported cytotoxic activities.