H
Hazel H. Szeto
Researcher at Cornell University
Publications - 51
Citations - 7298
Hazel H. Szeto is an academic researcher from Cornell University. The author has contributed to research in topics: Mitochondrion & Elamipretide. The author has an hindex of 26, co-authored 47 publications receiving 6296 citations. Previous affiliations of Hazel H. Szeto include Hospital for Special Surgery & University of Washington.
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Journal ArticleDOI
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Ethan J. Anderson,Mary E. Lustig,Kristen E. Boyle,Tracey L. Woodlief,Daniel A. Kane,Chien-Te Lin,Jesse W. Price,Li Kang,Peter S. Rabinovitch,Hazel H. Szeto,Joseph A. Houmard,Ronald N. Cortright,David H. Wasserman,P. Darrell Neufer +13 more
TL;DR: It is shown that in skeletal muscle of both rodents and humans, a diet high in fat increases the H(2)O(2)-emitting potential of mitochondria, shifts the cellular redox environment to a more oxidized state, and decreases the redox-buffering capacity in the absence of any change in mitochondrial respiratory function.
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Cell-permeable Peptide Antioxidants Targeted to Inner Mitochondrial Membrane inhibit Mitochondrial Swelling, Oxidative Cell Death, and Reperfusion Injury
TL;DR: Overproduction of ROS underlies the cellular toxicity of tBHP and 3NP, and ROS mediate cytochrome c release via MPT, and these IMM-targeted antioxidants may be very beneficial in the treatment of aging and diseases associated with oxidative stress.
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Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons
Maria Manczak,Peizhong Mao,Markus J. Calkins,Anda Cornea,Arubala P. Reddy,Michael P. Murphy,Hazel H. Szeto,Byung Park,P. Hemachandra Reddy,P. Hemachandra Reddy +9 more
TL;DR: It is suggested that MitoQ and SS31 prevent Abeta toxicity, which would warrant the study of MitoZ andSS31 as potential drugs to treat patients with AD.
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First‐in‐class cardiolipin‐protective compound as a therapeutic agent to restore mitochondrial bioenergetics
TL;DR: SS‐31 represents a new class of compounds that can recharge the cellular powerhouse and restore bioenergetics and provides an update of its clinical development programme.
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A role for heterodimerization of μ and δ opiate receptors in enhancing morphine analgesia
TL;DR: It is shown that μ-δ interacting complexes exist in live cells and native membranes and that the occupancy of δ receptors is sufficient to enhance μ opioid receptor binding and signaling activity, and that δ receptor antagonists enhance morphine-mediated intrathecal analgesia.