P
Peter S. Rabinovitch
Researcher at University of Washington
Publications - 342
Citations - 32434
Peter S. Rabinovitch is an academic researcher from University of Washington. The author has contributed to research in topics: Dysplasia & Cancer. The author has an hindex of 89, co-authored 325 publications receiving 29893 citations. Previous affiliations of Peter S. Rabinovitch include Fred Hutchinson Cancer Research Center & University of Tennessee.
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Journal ArticleDOI
Extension of murine life span by overexpression of catalase targeted to mitochondria.
Samuel E. Schriner,Nancy J. Linford,George M. Martin,Piper M. Treuting,Charles E. Ogburn,Mary J. Emond,Pinar Coskun,Warren Ladiges,Norman S. Wolf,Holly Van Remmen,Douglas C. Wallace,Peter S. Rabinovitch +11 more
TL;DR: Transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or mitochondria were generated and the importance of mitochondria as a source of radicals was reinforced.
Journal ArticleDOI
mTOR is a key modulator of ageing and age-related disease
TL;DR: Although adverse side effects currently preclude use in otherwise healthy individuals, drugs that target the mTOR pathway could one day become widely used to slow ageing and reduce age-related pathologies in humans.
Journal ArticleDOI
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Ethan J. Anderson,Mary E. Lustig,Kristen E. Boyle,Tracey L. Woodlief,Daniel A. Kane,Chien-Te Lin,Jesse W. Price,Li Kang,Peter S. Rabinovitch,Hazel H. Szeto,Joseph A. Houmard,Ronald N. Cortright,David H. Wasserman,P. Darrell Neufer +13 more
TL;DR: It is shown that in skeletal muscle of both rodents and humans, a diet high in fat increases the H(2)O(2)-emitting potential of mitochondria, shifts the cellular redox environment to a more oxidized state, and decreases the redox-buffering capacity in the absence of any change in mitochondrial respiratory function.
Journal ArticleDOI
Genetic clonal diversity predicts progression to esophageal adenocarcinoma
Carlo C. Maley,Patricia C. Galipeau,Jennifer C. Finley,V. Jon Wongsurawat,Xiaohong Li,Carissa A. Sanchez,Thomas G. Paulson,Patricia L. Blount,Patricia L. Blount,Rosa Ana Risques,Peter S. Rabinovitch,Peter S. Rabinovitch,Brian J. Reid +12 more
TL;DR: It is shown that clonal diversity measures adapted from ecology and evolution can predict progression to adenocarcinoma in the premalignant condition known as Barrett's esophagus, even when controlling for established genetic risk factors.
Reference BookDOI
Current protocols in cytometry
J. Paul Robinson,Zbigniew Darzynkiewicz,Robert A. Hoffman,John P. Nolan,Peter S. Rabinovitch,Simon C. Watkins +5 more
TL;DR: Current Protocols in Cytometry (CPC), published in affiliation with the International Society for Analytical Cytology, features carefully edited flow and image cytometry methods provided by leading laboratories from around the world.