H
Heather A. Coverdale
Researcher at University of Minnesota
Publications - 7
Citations - 236
Heather A. Coverdale is an academic researcher from University of Minnesota. The author has contributed to research in topics: Iminium & Cycloaddition. The author has an hindex of 4, co-authored 7 publications receiving 228 citations.
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Journal ArticleDOI
Highly stereoselective synthesis of novel alpha-haloenamides via a mild and efficient hydrohalogenation of ynamides.
Jason A. Mulder,Kimberly C. M. Kurtz,Richard P. Hsung,Heather A. Coverdale,Michael O. Frederick,Lichun Shen,Craig A. Zificsak +6 more
TL;DR: A highly stereoselective preparation of novel chiral (E)-alpha-haloenamides under mild conditions utilizing magnesium halide salts is described, highlighting another synthetic utility of ynamides.
Journal ArticleDOI
A Formal [3 + 3] Cycloaddition Reaction. Improved Reactivity Using α,β-Unsaturated Iminium Salts and Evidence for Reversibility of 6π-Electron Electrocyclic Ring Closure of 1-Oxatrienes
Hong C. Shen,Jiashi Wang,Kevin P. Cole,Michael J. McLaughlin,Christopher D. Morgan,Christopher J. Douglas,Richard P. Hsung,Heather A. Coverdale,Aleksey I. Gerasyuto,Juliet M. Hahn,Jia Liu,Heather M. Sklenicka,Lin-Li Wei,Luke R. Zehnder,Craig A. Zificsak +14 more
TL;DR: In this paper, a formal cycloaddition method using 4-hydroxy-2-pyrones and 1,3-diketones is described, and experimental evidence is provided to support the mechanism of this reaction that involves a sequential Knoevenagel condensation and a reversible 6π-electron electrocyclic ring closure of 1-oxatrienes.
Journal ArticleDOI
The total synthesis of (±)-arisugacin A
Richard P. Hsung,Kevin P. Cole,Luke R. Zehnder,Jiashi Wang,Lin-Li Wei,Xiao-Fang Yang,Heather A. Coverdale +6 more
TL;DR: A 20-step total synthesis of arisugacin A with an overall yield of 2.1% is described in detail in this paper, which features a formal [3+3] cycloaddition reaction of α,β-unsaturated iminium salts with 6-aryl-4-hydroxy-2-pyrones through a highly stereoselective 6π-electron electrocyclic ring closure of 1-oxatriene.
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Aza-[3+3] Annulations. Part 6. Total Synthesis of Putative (-)-Lepadiformine and (-)-Cylindricine C
Richard P. Hsung,Jiashi Wang,Jacob J. Swidorski,Nadiya Sydorenko,Heather A. Coverdale,Jennifer M. Kuyava,Jia Liu +6 more
TL;DR: In this paper, an enantioselective total synthesis of (-)-cylindricine C along with the syntheses of putative lepadiformine, epi-lepadiformines, (-)-4-deoxo-cylindRIC-C, and (-)-2-epi-cylINDRICine C are described in details.
Journal ArticleDOI
The Total Synthesis of (-)-Arisugacin A
Richard P. Hsung,Kevin P. Cole,Luke R. Zehnder,Jiashi Wang,Lin-Li Wei,Xiao-Fang Yang,Heather A. Coverdale +6 more
TL;DR: A 20-step total synthesis of arisugacin A with an overall yield of 2.1% is described in detail in this article, which features a formal [3+3] cycloaddition reaction of α,β-unsaturated iminium salts with 6-aryl-4-hydroxy-2-pyrones through a highly stereoselective 6π-electron electrocyclic ring closure of 1-oxatriene.