H
Heather E. Eaton
Researcher at Trent University
Publications - 11
Citations - 308
Heather E. Eaton is an academic researcher from Trent University. The author has contributed to research in topics: Ranavirus & Iridovirus. The author has an hindex of 7, co-authored 9 publications receiving 271 citations.
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Comparative genomic analysis of the family Iridoviridae : re-annotating and defining the core set of iridovirus genes
TL;DR: The re-analysis of genomes within the Iridoviridae family provides a unifying framework to understand the biology of these viruses, and further re-defining the core set of iridovirus genes will continue to lead to a better understanding of the phylogenetic relationships between individual irids.
Journal ArticleDOI
The genomic diversity and phylogenetic relationship in the family iridoviridae.
TL;DR: The phylogenetic relationship between individual iridoviruses was explored and the core-set of genes shared by all members of the family was defined, and each genome was found to contain a set of unique repetitive sequences that could be used in future virus identification.
Journal ArticleDOI
SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments.
Heather E. Eaton,Guillaume Desrochers,Samuel B. Drory,Julie Metcalf,Annie Angers,Craig R. Brunetti +5 more
TL;DR: It is demonstrated that LITAF is localized to the late endosome/lysosomal compartment in a variety of cell lines and it is shown that this re-localization is dependent upon the interaction with the PPXY sequences of LIT AF, since disruption of these binding motifs completely abrogates Itch re- localization.
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Cellular LITAF Interacts with Frog Virus 3 75L Protein and Alters Its Subcellular Localization
Heather E. Eaton,Andressa Ferreira Lacerda,Guillaume Desrochers,Julie Metcalf,Annie Angers,Craig R. Brunetti +5 more
TL;DR: It is shown that FV3 75L localizes to early endosomes, while LITAFLocalizes to late endosome/lysosome, and it is demonstrated that virally produced 75L colocalizes with LIT AF.
Journal ArticleDOI
Frog Virus 3 Open Reading Frame 97R Localizes to the Endoplasmic Reticulum and Induces Nuclear Invaginations
Brooke A. Ring,Andressa Ferreira Lacerda,Dylan J. Drummond,Christina Wangen,Heather E. Eaton,Craig R. Brunetti +5 more
TL;DR: FV3 ORF 97R contains a B-cell lymphoma 2 (Bcl-2) homology 1 (BH1) domain and has sequence similarity to the myeloid cell leukemia-1 (Mcl-1) protein, suggesting a potential role in apoptosis.