H
Heather M. Dungan
Researcher at University of Washington
Publications - 3
Citations - 1208
Heather M. Dungan is an academic researcher from University of Washington. The author has contributed to research in topics: Kisspeptin & Gonadotropin-releasing hormone. The author has an hindex of 3, co-authored 3 publications receiving 1134 citations.
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Journal ArticleDOI
Differential Regulation of KiSS-1 mRNA Expression by Sex Steroids in the Brain of the Male Mouse
Jeremy Troy Smith,Heather M. Dungan,Elizabeth A. Stoll,Michelle L. Gottsch,Robert E. Braun,Stephen M. Eacker,Donald K. Clifton,Robert A. Steiner +7 more
TL;DR: Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor, and the effects of T are mediated by both ERalpha and AR pathways, suggesting that both estrogen receptor (ER) and androgen receptor (AR) play a role in T-mediated regulation of KiSS-1.
Journal ArticleDOI
Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion.
TL;DR: Observations demonstrate that kisspeptin-GPR54 signaling in the brain serves as an important conduit for controlling GnRH secretion in the developing and adult animal.
Journal ArticleDOI
The role of kisspeptin-GPR54 signaling in the tonic regulation and surge release of gonadotropin-releasing hormone/luteinizing hormone
Heather M. Dungan,Michelle L. Gottsch,Hongkui Zeng,Alexander Gragerov,John E. Bergmann,Demetrios K. Vassilatis,Donald K. Clifton,Robert A. Steiner +7 more
TL;DR: It is found that GPR54 KO mice do not exhibit a postovariectomy rise in LH, suggesting that tonic GnRH secretion is disrupted in the absence of kisspeptin–GPR54 signaling, and Kiss1-expressing neurons are thought to regulate the secretion of gonadotropin-releasing hormone and thus coordinate the estrous cycle in rodents.