Elizabeth A. Stoll

TL;DR: Kisspeptins are products of the Kiss1 gene, which bind to GPR54, a G protein-coupled receptor, and the effects of T are mediated by both ERalpha and AR pathways, suggesting that both estrogen receptor (ER) and androgen receptor (AR) play a role in T-mediated regulation of KiSS-1.

TL;DR: The current state of knowledge regarding the metabolic strategies employed by malignant glioma cells, including aerobic glycolysis; the pentose phosphate pathway; one-carbon metabolism; the tricarboxylic acid cycle, which is central to amino acid metabolism; oxidative phosphorylation; and fatty acid metabolism are presented.

TL;DR: The results highlight the critical role for dopamine signaling in the dorsal striatum for most dopamine-dependent behaviors but suggest that dopamine signaled in other brain regions is important to fine-tune these behaviors.

TL;DR: It is demonstrated that this metabolic pathway is a major contributor to aerobic respiration in primary-cultured cells isolated from human glioma and grown under serum-free conditions and inhibiting fatty acid oxidation reduces proliferative activity in these primary- Cultured cells and prolongs survival in a syngeneic mouse model of malignant gliomas.

TL;DR: Higher levels of neurogenesis can be achieved in aged mice by ectopically expressing proliferator‐activated receptor gamma coactivator 1 alpha (PGC1α), a factor that increases cellular aerobic capacity by promoting mitochondrial biogenesis and metabolic gene transcription.