H
Hege Sletvold
Researcher at Nord University
Publications - 19
Citations - 466
Hege Sletvold is an academic researcher from Nord University. The author has contributed to research in topics: Enterococcus faecium & Medicine. The author has an hindex of 7, co-authored 16 publications receiving 395 citations. Previous affiliations of Hege Sletvold include University Hospital of North Norway & University of Tromsø.
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Journal ArticleDOI
PCR-based plasmid typing in Enterococcus faecium strains reveals widely distributed pRE25-, pRUM-, pIP501- and pHTβ-related replicons associated with glycopeptide resistance and stabilizing toxin–antitoxin systems
Torill C.S. Rosvoll,Torunn Pedersen,Hege Sletvold,Pål Jarle Johnsen,Johanna U. Ericson Sollid,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Lars Bogø Jensen,Kaare Magne Nielsen,Arnfinn Sundsfjord,Arnfinn Sundsfjord +11 more
TL;DR: PCR-based replicon typing, linked to the detection of other important plasmid-encoded traits, seems to be a feasible tool for tracing disseminating resistance plasmids stably maintained in various environments.
Journal ArticleDOI
Persistence of animal and human glycopeptide-resistant enterococci on two Norwegian poultry farms formerly exposed to avoparcin is associated with a widespread plasmid-mediated vanA element within a polyclonal enterococcus faecium population.
Pål Jarle Johnsen,J. I. Østerhus,Hege Sletvold,M. Sørum,Hilde Kruse,Kaare Magne Nielsen,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Arnfinn Sundsfjord,Arnfinn Sundsfjord +9 more
TL;DR: It is proposed that “plasmid addiction systems” may contribute to the persistence of GREF in nonselective environments as well as the notion that environmentally well-adapted GREF types may counteract the reversal of resistance.
Journal ArticleDOI
Comparative DNA Analysis of Two vanA Plasmids from Enterococcus faecium Strains Isolated from Poultry and a Poultry Farmer in Norway
Hege Sletvold,Pål Jarle Johnsen,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Bettina Aasnæs,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Kaare Magne Nielsen +9 more
TL;DR: Forty-three shared coding sequences were identified, and the only nucleotide difference was an 88-bp indel, which possibly explains the persistence of the vanA gene cluster in Norwegian poultry farms.
Journal ArticleDOI
Complete sequence of Enterococcus faecium pVEF3 and the detection of an omega-epsilon-zeta toxin-antitoxin module and an ABC transporter.
Hege Sletvold,Pål Jarle Johnsen,I. Hamre,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Kaare Magne Nielsen +8 more
TL;DR: Plasmid stability tests and transcription analysis show that omega-epsilon-zeta is functional in Enterococcus faecalis OGIX, although with decreasing effect over time, and the TA system identified in the pVEF-type plasmids may contribute to vanA plasmid persistence on Norwegian poultry farms.
Journal ArticleDOI
Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages
Hege Sletvold,Pål Jarle Johnsen,Odd-Gunnar Wikmark,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Gunnar Skov Simonsen,Arnfinn Sundsfjord,Arnfinn Sundsfjord,Kaare Magne Nielsen +8 more
TL;DR: Comparative DNA analyses suggest that Tn1546 disseminates in and between clonal complexes of E. faecium as part of a larger genetic unit, possibly as a composite transposon flanked by IS1216 elements.