H
Heidi E. Drummer
Researcher at Burnet Institute
Publications - 117
Citations - 4163
Heidi E. Drummer is an academic researcher from Burnet Institute. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 35, co-authored 105 publications receiving 3752 citations. Previous affiliations of Heidi E. Drummer include St. Vincent's Institute of Medical Research & University of Melbourne.
Papers
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Journal ArticleDOI
Claudin Association with CD81 Defines Hepatitis C Virus Entry
Helen J. Harris,Christopher Davis,Jonathan G. L. Mullins,Ke Hu,Margaret Goodall,Michelle J. Farquhar,Christopher J. Mee,Kitty McCaffrey,Stephen Young,Heidi E. Drummer,Peter Balfe,Jane A. McKeating +11 more
TL;DR: An essential role for Claudin-CD81 complexes in HCV infection and their localization at the basolateral surface of polarized hepatoma cells, consistent with virus entry into the liver via the sinusoidal blood and association with basal expressed forms of the receptors is demonstrated.
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Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence.
Gemma E. Hartley,Emily S.J. Edwards,Pei M. Aui,Nirupama Varese,Stephanie Stojanovic,James H McMahon,Anton Y. Peleg,Anton Y. Peleg,Irene Boo,Heidi E. Drummer,Heidi E. Drummer,Heidi E. Drummer,P. Mark Hogarth,P. Mark Hogarth,P. Mark Hogarth,Robyn E O'Hehir,Menno C. van Zelm +16 more
TL;DR: In this paper, fluorescently-labeled tetramers of the spike receptor binding domain (RBD) and nucleocapsid protein (NCP) were used to determine the longevity and immunophenotype of SARS-CoV-2-specific Bmem cells in COVID-19 patients.
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Cell surface expression of functional hepatitis C virus E1 and E2 glycoproteins
TL;DR: The detection of E1 and E2 at the surface of transiently transfected HEK 293T and Huh7 cells is described and suggest that functional HCV glycoproteins are not retained exclusively in the ER and transit through the secretory pathway.
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Identification of a Residue in Hepatitis C Virus E2 Glycoprotein That Determines Scavenger Receptor BI and CD81 Receptor Dependency and Sensitivity to Neutralizing Antibodies
Joe Grove,Søren Nielsen,Jin Zhong,Margaret F. Bassendine,Heidi E. Drummer,Peter Balfe,Jane A. McKeating +6 more
TL;DR: Mutation of E2 at position 451 alters the relationship between particle density and infectivity, disrupts coreceptor dependence, and increases virion sensitivity to receptor mimics and NAbs, suggesting the evasion of host immune responses.
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A Conserved Gly436-Trp-Leu-Ala-Gly-Leu-Phe-Tyr Motif in Hepatitis C Virus Glycoprotein E2 Is a Determinant of CD81 Binding and Viral Entry
TL;DR: Findings indicate that the G436WLAGLFY motif of E2 functions in CD81 binding and in pre- or post-CD81-dependent stages of viral entry, suggesting that the CD81binding site undergoes a conformational transition during glycoprotein maturation through the secretory pathway.