Joe Grove

TL;DR: The cell imposes multiple barriers to virus entry, but viruses exploit fundamental cellular processes to gain entry to cells and deliver their genetic cargo.

TL;DR: It is demonstrated that, in contrast to earlier reports, CD81 and the tight-junction components claudin-1 and occludin are all essential for both cell-free and cell-to-cell viral transmission of Hepatitis C virus, however, scavenger receptor BI (SR-BI) has a more prominent role in cell- to-cell transmission of the virus.

TL;DR: Although inhibition of in vitro NS5B polymerase activity is demonstrable, the mechanisms of silymarin's antiviral action appear to include blocking of virus entry and transmission, possibly by targeting the host cell.

TL;DR: In this article , the authors demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273.529.

TL;DR: Mutation of E2 at position 451 alters the relationship between particle density and infectivity, disrupts coreceptor dependence, and increases virion sensitivity to receptor mimics and NAbs, suggesting the evasion of host immune responses.