H
Heidi R. Bokesch
Researcher at National Institutes of Health
Publications - 11
Citations - 9432
Heidi R. Bokesch is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Chemistry & Scytovirin. The author has an hindex of 6, co-authored 9 publications receiving 8853 citations. Previous affiliations of Heidi R. Bokesch include Science Applications International Corporation.
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Journal ArticleDOI
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
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A Potent Novel Anti-HIV Protein from the Cultured Cyanobacterium Scytonema varium†
Heidi R. Bokesch,Barry R. O'Keefe,Tawnya C. McKee,Lewis K. Pannell,Gregory M. L. Patterson,Roberta S. Gardella,Raymond C. Sowder,Jim A. Turpin,Karen Watson,Robert W. Buckheit,Michael R. Boyd +10 more
TL;DR: A new anti-HIV protein, scytovirin, was isolated from aqueous extracts of the cultured cyanobacterium Scytonema varium and displayed potent anticytopathic activity against laboratory strains and primary isolates of HIV-1 with EC50 values ranging from 0.3 to 22 nM.
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A novel anti-HIV macrocyclic peptide from Palicourea condensata.
Heidi R. Bokesch,Lewis K. Pannell,Pamela K. Cochran,Raymond C. Sowder,Tawnya C. McKee,Michael R. Boyd +5 more
TL;DR: Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50value of 1.5 microM.
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The Novel Fold of Scytovirin Reveals a New Twist For Antiviral Entry Inhibitors
Robert L. McFeeters,Changyun Xiong,Barry R. O'Keefe,Heidi R. Bokesch,Heidi R. Bokesch,James B. McMahon,Daniel M. Ratner,Riccardo Castelli,Peter H. Seeberger,R. Andrew Byrd +9 more
TL;DR: Scytovirin, originally isolated from the cyanobacterium Scytonema varium, holds potential as an HIV entry inhibitor for both therapeutic and prophylactic anti-HIV applications and high-resolution structural studies reported are an important initial step in unlocking the therapeutic potential of scytovirin.
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Preparative separation of naphthyltetrahydroisoquinoline alkaloids from Ancistrocladus korupensis by centrifugal partition chromatography
Yali F. Hallock,Jin-Rui Dai,Heidi R. Bokesch,Kaye B. Dillah,Kirk P. Manfredi,John H. Cardellina,Michael R. Boyd +6 more
TL;DR: A refined, three-step process (solvent-solvent partitioning, centrifugal partition chromatography and HPLC) has been developed and applied to the scaled-up production of michellamine B for preclinical drug development.