H
Heike Lange
Researcher at University of Marburg
Publications - 11
Citations - 1995
Heike Lange is an academic researcher from University of Marburg. The author has contributed to research in topics: Mitochondrion & Biogenesis. The author has an hindex of 10, co-authored 11 publications receiving 1923 citations. Previous affiliations of Heike Lange include Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
An essential function of the mitochondrial sulfhydryl oxidase Erv1p/ALR in the maturation of cytosolic Fe/S proteins.
TL;DR: The essential Erv1p of Saccharomyces cerevisia mitochondria is identified as a novel component that is specifically required for the maturation of Fe/S proteins in the cytosol, but not in mitochondria.
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A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins
TL;DR: Yah1p of Saccharomyces cerevisiae mitochondria is the first member of the ferredoxin family for which a function in Fe/S cluster formation has been established and lends support to the idea of a primary function of mitochondria in the biosynthesis ofFe/S proteins outside the organelle.
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A mutation of the mitochondrial ABC transporter Sta1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik
Sergei Kushnir,Elena Babiychuk,Sergei Storozhenko,Mark W. Davey,Jutta Papenbrock,Riet De Rycke,Gilbert Engler,Udo W. Stephan,Heike Lange,Gyula Kispal,Roland Lill,Marc Van Montagu +11 more
TL;DR: It is suggested that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters.
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Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation
Soumeya Bekri,Gyula Kispal,Gyula Kispal,Gyula Kispal,Heike Lange,Edward Fitzsimons,John Tolmie,Roland Lill,David F. Bishop +8 more
TL;DR: It is demonstrated that both the molecular defect in XLSA/A and the impaired maturation of a cytosolic Fe/S protein result from an ABC7 mutation in the reported family.
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Biogenesis of cytosolic ribosomes requires the essential iron-sulphur protein Rli1p and mitochondria
Gyula Kispal,Katalin Sipos,Heike Lange,Zsuzsanna Fekete,Tibor Bedekovics,Tamás Janáky,Jochen Bassler,Daili J. A. Netz,Janneke Balk,Carmen Rotte,Roland Lill +10 more
TL;DR: The essential character of Fe/S clusters in Rli1p explains the indispensable character of mitochondria in eukaryotes and is associated with ribosomes and with Hcr1p, a protein involved in rRNA processing and translation initiation.