H
Helen K. Scott
Researcher at University of Bristol
Publications - 8
Citations - 452
Helen K. Scott is an academic researcher from University of Bristol. The author has contributed to research in topics: Enantioselective synthesis & Selectivity. The author has an hindex of 5, co-authored 8 publications receiving 395 citations.
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Journal ArticleDOI
Enantioselective construction of quaternary stereogenic centers from tertiary boronic esters: methodology and applications.
Ravindra P. Sonawane,Vishal Jheengut,Constantinos Rabalakos,Robin Larouche-Gauthier,Helen K. Scott,Varinder K. Aggarwal +5 more
TL;DR: The creation of quaternary stereogenic centers with high enantioselectivity is challenging, in part, because of the high steric repulsion between the substituents on the carbon center that is generated during construction.
Journal ArticleDOI
Highly enantioselective synthesis of tertiary boronic esters and their stereospecific conversion to other functional groups and quaternary stereocentres.
TL;DR: An efficient methodology for the highly enantioselective synthesis of tertiary boronic esters from the corresponding secondary benzylic alcohols is developed.
Journal ArticleDOI
Highly Diastereo- and Enantioselective Allylboration of Aldehydes using α-Substituted Allyl/Crotyl Pinacol Boronic Esters via in Situ Generated Borinic Esters
TL;DR: It is found that addition of nBuLi to the pinacol boronic ester followed by trapping of the alkoxide with TFAA leads to an intermediate allyl borinic ester which undergoes allylboration with very high E selectivity.
Journal ArticleDOI
Selective uni- and bidirectional homologation of diborylmethane
Daniel J. Blair,Damiano Tanini,Joseph M. Bateman,Helen K. Scott,Eddie L. Myers,Varinder K. Aggarwal +5 more
TL;DR: In this article, the authors used enantiomerically pure lithium-stabilized carbenoids to give 1,2- and 1,3-bis(boronic esters), respectively, in good yield and with excellent levels of enantio-and diastereoselectivity.