H
Helen M. Burt
Researcher at University of British Columbia
Publications - 200
Citations - 9872
Helen M. Burt is an academic researcher from University of British Columbia. The author has contributed to research in topics: Controlled release & Micelle. The author has an hindex of 52, co-authored 200 publications receiving 9291 citations. Previous affiliations of Helen M. Burt include University of Texas Medical Branch & Hastings Entertainment.
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Journal ArticleDOI
A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes.
Kevin Letchford,Helen M. Burt +1 more
TL;DR: This review attempts to clarify some of the terminology used in the literature by providing an overview of the major features of each type of nanoparticle and the factors that influence the formation of particular nanoparticulate formulations.
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Development of amphiphilic diblock copolymers as micellar carriers of taxol
TL;DR: Evidence of strong association or binding of taxol to the PDLLA block of the copolymer even below the polymer CMC is presented, which indicates that polymeric micelles with hydrophobic poly(DL-lactide) (PDLLA) core and a water soluble MePEG shell are feasible for high-performance liquid chromatography.
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The use of nanocrystalline cellulose for the binding and controlled release of drugs
TL;DR: The objective of this work was to investigate the use of nanocrystalline cellulose (NCC) as a drug delivery excipient, and NCC crystallites, prepared by an acid hydrolysis method, were shown to have nanoscopic dimensions and exhibit a high degree of crystallinity.
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Polyether-polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations.
Richard Liggins,Helen M. Burt +1 more
TL;DR: The synthetic reaction conditions influencing the degree of conversion of monomer to copolymer, thermal properties, critical micelle concentrations of copolymers, methods of incorporation of paclitaxel intoCopolymer matrices and subsequent constitution in aqueous media are described and biological evaluations of micellar pac litaxel are described.
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Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
TL;DR: The results of a range of in vitro and in vivoBiocompatibility/toxicology tests in animals showed the PDLLA–MePEG micelles to be biocompatible and non-toxic.