H
Helen R Valentine
Researcher at Manchester Academic Health Science Centre
Publications - 37
Citations - 1647
Helen R Valentine is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Adenocarcinoma & Gene signature. The author has an hindex of 19, co-authored 36 publications receiving 1442 citations. Previous affiliations of Helen R Valentine include University of Manchester.
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Journal ArticleDOI
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers.
Stuart Winter,Francesca M. Buffa,Priyamal Silva,Crispin J. Miller,Helen R Valentine,Helen Turley,Ketan A. Shah,Graham J. Cox,Rogan Corbridge,Jarrod J Homer,B.T. Musgrove,Nicholas J Slevin,Philip Sloan,Patricia M Price,Catharine M L West,Adrian L. Harris +15 more
TL;DR: The work highlights the validity and potential of using data from analysis of in vitro stress pathways for deriving a biological metagene/gene signature in vivo and outdoing the original intrinsic classifier.
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Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.
Gillian J. Hutchison,Helen R Valentine,Juliette A Loncaster,Susan E Davidson,Robert D. Hunter,Stephen A Roberts,Adrian L. Harris,Ian J. Stratford,Patricia M Price,Catharine M L West +9 more
TL;DR: The possible switch in large tumors for an association between high HIF-1alpha expression and good outcome might relate to tumor size-related changes in the balance of genes up-regulated by Hif-1 alpha, Whereas angiogenesis-promoting genes might be preferentially up- regulated in small tumors, proapoptotic genes might been induced in large tumor.
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Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation
John Simon Hall,Janet Taylor,Helen R Valentine,Joely J Irlam,Amanda Eustace,Peter Hoskin,Crispin J. Miller,Catharine M L West +7 more
TL;DR: Sample age is the best predictor of successful mRNA profiling of FFPE material, and miRNA profiling overcomes the limitation of age and copes well with older samples.
Journal ArticleDOI
Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma?
Rachel A Cooper,Sulen Sarioglu,Selman Sökmen,Mehmet Füzün,Ali Küpelioğlu,Helen R Valentine,İlknur Bilkay Görken,Rachel Airley,Catharine M L West +8 more
TL;DR: Increased GLUT-1 expression in rectal tumours was an adverse prognostic factor and is worth further evaluation as a predictive marker of response to therapy.
Journal ArticleDOI
Hypoxia-inducible factor-1alpha expression in the gastric carcinogenesis sequence and its prognostic role in gastric and gastro-oesophageal adenocarcinomas.
Ewen A. Griffiths,Susan Pritchard,Helen R Valentine,N Whitchelo,P W Bishop,Matthias P. A. Ebert,Patricia M Price,I. Welch,Catharine M L West +8 more
TL;DR: The results suggest HIF-1α is involved in gastric carcinogenesis and disease progression, but is only a weak prognostic factor for survival.