H
Hélène Bastuji
Researcher at French Institute of Health and Medical Research
Publications - 87
Citations - 3946
Hélène Bastuji is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Non-rapid eye movement sleep & Narcolepsy. The author has an hindex of 30, co-authored 80 publications receiving 3217 citations. Previous affiliations of Hélène Bastuji include Lyons & University of Lyon.
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A differential brain response to the subject's own name persists during sleep.
TL;DR: The sleeping brain, during SII and PS, elicits a differential cognitive response to the presentation of the subject's own name, comparable to that occurring during wakefulness, and therefore that the sleeping brain is able to detect and categorize some particular aspects of stimulus significance.
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Sleep and Alzheimer's disease
Laure Peter-Derex,Laure Peter-Derex,Pierre Yammine,Hélène Bastuji,Hélène Bastuji,Bernard Croisile +5 more
TL;DR: The presence of sleep complaints, especially excessive somnolence in demented patients, should draw attention to possible associated sleep pathologies such as sleep apnea syndrome or restless legs syndrome.
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Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil.
Hélène Bastuji,M Jouvet +1 more
TL;DR: Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy and produces, in most cases, no peripheric sides effects, does not disturb night sleep and is never responsible of tolerance of drug dependence.
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An inverse agonist of the histamine h3-receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients
Jian-Sheng Lin,Yves Dauvilliers,Isabelle Arnulf,Hélène Bastuji,Christelle Anaclet,Régis Parmentier,Laurence Kocher,Masashi Yanagisawa,Philippe Lehert,Xavier Ligneau,Perrin David,Philippe Robert,Michel Roux,Jeanne Marie Lecomte,Jean Schwartz +14 more
TL;DR: H(3)-receptor inverse agonists could constitute a novel effective treatment of EDS, particularly when associated with modafinil, a currently-prescribed wake-promoting drug.
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Thalamic deactivation at sleep onset precedes that of the cerebral cortex in humans
Michel Magnin,Marc Rey,Hélène Bastuji,Philippe Guillemant,François Mauguière,Luis Garcia-Larrea +5 more
TL;DR: Using simultaneous intracortical and intrathalamic recordings, it is demonstrated that the thalamic deactivation occurring at sleep onset most often precedes that of the cortex by several minutes, whereas reactivation of both structures during awakening is synchronized.