J
Jean Schwartz
Researcher at French Institute of Health and Medical Research
Publications - 88
Citations - 2320
Jean Schwartz is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Dopamine receptor & Receptor. The author has an hindex of 25, co-authored 88 publications receiving 2284 citations.
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Journal ArticleDOI
Amino acid substitution in the dopamine D3 receptor as a useful polymorphism for investigating psychiatric disorders
L. Lannfelt,Pierre Sokoloff,M.-P. Martres,C. Pilon,B. Giros,Erik G. Jönsson,Göran Sedvall,Jean Schwartz +7 more
TL;DR: A point mutation in the gene that creates a Ball restriction enzyme site and leads to a substitution of a Serine by a Glycine residue in the 5′ part of the receptor gene is detected.
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An inverse agonist of the histamine h3-receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patients
Jian-Sheng Lin,Yves Dauvilliers,Isabelle Arnulf,Hélène Bastuji,Christelle Anaclet,Régis Parmentier,Laurence Kocher,Masashi Yanagisawa,Philippe Lehert,Xavier Ligneau,Perrin David,Philippe Robert,Michel Roux,Jeanne Marie Lecomte,Jean Schwartz +14 more
TL;DR: H(3)-receptor inverse agonists could constitute a novel effective treatment of EDS, particularly when associated with modafinil, a currently-prescribed wake-promoting drug.
Journal ArticleDOI
Long-term changes in the sensitivity of pre-and postsynaptic dopamine receptors in mouse striatum evidenced by behavioural and biochemical studies.
Marie-Pascale Martres,Jean Costentin,Michel Baudry,H. Marcais,Philippe Protais,Jean Schwartz +5 more
TL;DR: The hyposensitivity of DA ‘autoreceptors’, responding to low doses of DA agonists, mediating an inhibition of DA release and, consequently, behavioural effects opposite to those resulting from the stimulation of postsynaptic receptors, may explain the ‘behavioural facilitation’.
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The nucleus reticularis lateralis: a region highly sensitive to clonidine.
TL;DR: Slow bilateral microinjections of a low dose of clonidine in the cat's nucleus reticularis lateralis (NRL) lead to significant hypotension and bradycardia, confirming the existence of a ventromedullary highly sensitive site of action ofClonidine.
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Identification of aminopeptidase M as an enkephalin-inactivating enzyme in rat cerebral membranes
TL;DR: Aminopeptidase M (EC 3.4.11.2) was found to occur in brain, and the role of this enzyme in inactivating endogenous enkephalins released from their neuronal stores is suggested.