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Helmut Eiffert

Researcher at University of Göttingen

Publications -  104
Citations -  3948

Helmut Eiffert is an academic researcher from University of Göttingen. The author has contributed to research in topics: Borrelia burgdorferi & Lyme disease. The author has an hindex of 31, co-authored 101 publications receiving 3472 citations.

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Journal ArticleDOI

Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections

Roland Nau, +2 more
- 01 Oct 2010 - 
TL;DR: The ideal compound to treat CNS infections is of small molecular size, is moderately lipophilic, has a low level of plasma protein binding, and is not a strong ligand of an efflux pump at the blood-brain or blood-CSF barrier.
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Modulation of Release of Proinflammatory Bacterial Compounds by Antibacterials: Potential Impact on Course of Inflammation and Outcome in Sepsis and Meningitis

Roland Nau, +1 more
- 01 Jan 2002 - 
TL;DR: Substantial evidence for the validity of the concept of modulating the release of proinflammatory bacterial compounds by antibacterials has been accumulated in vitro and in animal experiments to justify clinical trials in sepsis and meningitis.
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Epidemiology and clinical manifestations of lyme borreliosis in childhood : a prospective multicentre study with special regard to neuroborreliosis

Hans-Jürgen Christen, +3 more
- 01 Feb 1993 - 
TL;DR: Lyme borreliosis proved to be the most frequently verifiable cause of acute peripheral facial palsy in children, causing every second case of this disorder in summer and autumn.
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Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.

Sandra Ribes, +11 more
- 01 Feb 2010 - 
TL;DR: Microglial stimulation by these TLRs may increase the resistance of the brain against pneumococcal infections, and the intracellular bacterial killing was increased in TLR-stimulated cells compared to unstimulated cells.
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Diversity of OspA and OspC among cerebrospinal fluid isolates of Borrelia burgdorferi sensu lato from patients with neuroborreliosis in Germany.

Bettina Wilske, +6 more
- 01 Feb 1996 - 
TL;DR: Since OspA and OspC are the most promising candidates for a Borrelia vaccine, the considerable heterogeneity found among CSF isolates has important implications for development of a vaccine in Europe.