Heloisa Sawaya

TL;DR: In this article, the authors investigated whether early alterations of myocardial strain and blood biomarkers predict incident cardiotoxicity in patients with breast cancer during treatment with anthracyclines, taxanes, and trastuzumab.

TL;DR: Cardiac troponin plasma concentrations and longitudinal strain predict the development of cardiotoxicity in patients treated with anthracyclines and trastuzumab, and the 2 parameters may be useful to detect chemotherapy-treated patients who may benefit from alternative therapies, potentially decreasing the incidence ofCardiotoxicity and its associated morbidity and mortality.

TL;DR: Early increases in TnI and MPO levels offer additive information about the risk of cardiotoxicity in patients undergoing doxorubicin and trastuzumab therapy, and independent validation is necessary before application to clinical practice.

TL;DR: Increases in MPO are associated with cardiotoxicity over the entire course of doxorubicin and trastuzumab therapy, and MPO was robust to alternative outcome definitions.

TL;DR: The use of NIR imaging microcatheters combined with protease-activatable smart probes results in a beacon effect that highlights tumors with high TBRs; this technique thus may be a potentially useful adjunct to white light colonoscopy in the future.