Early detection and prediction of cardiotoxicity in chemotherapy-treated patients.
Heloisa Sawaya,Igal A. Sebag,Juan Carlos Plana,James L. Januzzi,Bonnie Ky,Victor Cohen,Sucheta Gosavi,Joseph R. Carver,Susan E. Wiegers,Randolph P. Martin,Michael H. Picard,Robert E. Gerszten,Elkan F. Halpern,Jonathan J. Passeri,Irene Kuter,Marielle Scherrer-Crosbie +15 more
TLDR
Cardiac troponin plasma concentrations and longitudinal strain predict the development of cardiotoxicity in patients treated with anthracyclines and trastuzumab, and the 2 parameters may be useful to detect chemotherapy-treated patients who may benefit from alternative therapies, potentially decreasing the incidence ofCardiotoxicity and its associated morbidity and mortality.Abstract:
As breast cancer survival increases, cardiotoxicity associated with chemotherapeutic regimens such as anthracyclines and trastuzumab becomes a more significant issue. Assessment of the left ventricular (LV) ejection fraction fails to detect subtle alterations in LV function. The objective of this study was to evaluate whether more sensitive echocardiographic measurements and biomarkers could predict future cardiac dysfunction in chemotherapy-treated patients. Forty-three patients diagnosed with breast cancer who received anthracyclines and trastuzumab therapy underwent echocardiography and blood sampling at 3 time points (baseline and 3 and 6 months during the course of chemotherapy). The LV ejection fraction; peak systolic myocardial longitudinal, radial, and circumferential strain; echocardiographic markers of diastolic function; N-terminal pro–B-type natriuretic peptide; and high-sensitivity cardiac troponin I were measured. Nine patients (21%) developed cardiotoxicity (1 at 3 months and 8 at 6 months) as defined by the Cardiac Review and Evaluation Committee reviewing trastuzumab. A decrease in longitudinal strain from baseline to 3 months and detectable high-sensitivity cardiac troponin I at 3 months were independent predictors of the development of cardiotoxicity at 6 months. The LV ejection fraction, parameters of diastolic function, and N-terminal pro–B-type natriuretic peptide did not predict cardiotoxicity. In conclusion, cardiac troponin plasma concentrations and longitudinal strain predict the development of cardiotoxicity in patients treated with anthracyclines and trastuzumab. The 2 parameters may be useful to detect chemotherapy-treated patients who may benefit from alternative therapies, potentially decreasing the incidence of cardiotoxicity and its associated morbidity and mortality.read more
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2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
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TL;DR: In this article, Anderson et al. proposed a new FAHA Chair, Jeffrey L. Anderson, MD, FACC, FAHA, Chair-Elect, Alice K. Jacobs et al., this article and Biykem Bozkurt.
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Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
Juan Carlos Plana,Maurizio Galderisi,Ana Barac,Michael S. Ewer,Bonnie Ky,Marielle Scherrer-Crosbie,Javier Ganame,Igal A. Sebag,Deborah A. Agler,Luigi P. Badano,Jose Banchs,Daniela Cardinale,Joseph R. Carver,Manuel D. Cerqueira,Jeanne M. DeCara,Thor Edvardsen,Scott D. Flamm,Thomas Force,Brian P. Griffin,Guy Jerusalem,Jennifer E. Liu,Andreia Magalhaes,Thomas H. Marwick,Liza Y. Sanchez,Rosa Sicari,Hector R. Villarraga,Patrizio Lancellotti +26 more
TL;DR: The noninvasive evaluation of LVEF has gained importance, and notwithstanding the limitations of the techniques used for its calculation, has emerged as the most widely used strategy for monitoring the changes in cardiac function, both during and after the administration of potentially car- diotoxic cancer treatment.
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Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.
Juan Carlos Plana,Maurizio Galderisi,Ana Barac,Michael S. Ewer,Bonnie Ky,Marielle Scherrer-Crosbie,Javier Ganame,Igal A. Sebag,Deborah A. Agler,Luigi P. Badano,Jose Banchs,Daniela Cardinale,Joseph R. Carver,Manuel D. Cerqueira,Jeanne M. DeCara,Thor Edvardsen,Scott D. Flamm,Thomas Force,Brian P. Griffin,Guy Jerusalem,Jennifer E. Liu,Andreia Magalhaes,Thomas H. Marwick,Liza Y. Sanchez,Rosa Sicari,Hector R. Villarraga,Patrizio Lancellotti +26 more
TL;DR: The non-invasive evaluation of LVEF has gained importance, and notwithstanding the limitations of the techniques used for its calculation, has emerged as the most widely used strategy for monitoring the changes in cardiac function, both during and after the administration of potentially cardiotoxic cancer treatment.
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Use of myocardial strain imaging by echocardiography for the early detection of cardiotoxicity in patients during and after cancer chemotherapy: a systematic review.
Paaladinesh Thavendiranathan,Frédéric Poulin,Ki-Dong Lim,Juan Carlos Plana,Anna Woo,Thomas H. Marwick +5 more
TL;DR: The value of echocardiographicMyocardial deformation parameters for the early detection of myocardial changes and prediction of cardiotoxicity in patients receiving cancer therapy is confirmed.
Journal ArticleDOI
Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab
Heloisa Sawaya,Igal A. Sebag,Juan Carlos Plana,James L. Januzzi,Bonnie Ky,Bonnie Ky,Timothy C. Tan,Victor Cohen,Jose Banchs,Joseph R. Carver,Joseph R. Carver,Susan E. Wiegers,Susan E. Wiegers,Randolph P. Martin,Michael H. Picard,Robert E. Gerszten,Elkan F. Halpern,Jonathan J. Passeri,Irene Kuter,Marielle Scherrer-Crosbie +19 more
TL;DR: In this article, the authors investigated whether early alterations of myocardial strain and blood biomarkers predict incident cardiotoxicity in patients with breast cancer during treatment with anthracyclines, taxanes, and trastuzumab.
References
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Journal ArticleDOI
Prognostic Value of Troponin I in Cardiac Risk Stratification of Cancer Patients Undergoing High-Dose Chemotherapy
Daniela Cardinale,Maria T. Sandri,Alessandro Colombo,Nicola Colombo,Marina Boeri,Giuseppina Lamantia,Maurizio Civelli,Fedro A. Peccatori,Giovanni Martinelli,Cesare Fiorentini,Carlo M. Cipolla +10 more
TL;DR: TnI release pattern after high-dose chemotherapy identifies patients at different risks of cardiac events in the 3 years thereafter, and stratification allows the monitoring program and to plan, in selected patients, preventive strategies aimed at improving clinical outcome.
Journal ArticleDOI
Assessment of Cardiac Dysfunction in a Randomized Trial Comparing Doxorubicin and Cyclophosphamide Followed by Paclitaxel, With or Without Trastuzumab As Adjuvant Therapy in Node-Positive, Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer: NSABP B-31
Elizabeth Tan-Chiu,Greg Yothers,Edward H. Romond,Charles E. Geyer,Michael S. Ewer,Deborah Keefe,Richard P. Shannon,Sandra M. Swain,Ann M. Brown,Louis Fehrenbacher,Victor G. Vogel,Thomas E. Seay,Priya Rastogi,Eleftherios P. Mamounas,Norman Wolmark,John Bryant +15 more
TL;DR: Administering trastuzumab with paclitaxel after AC increases incidence of congestive heart failure and lesser CD, and potential cardiotoxicity should be carefully considered when discussing benefits and risks of this therapy.
Book
Principles and Practice of Echocardiography
TL;DR: Part 1 Physical principles, instrumentation, and routine examination: physical principles of ultrasound cross-sectional scanning, technical principles and instrumentation digital image processingCross-sectional echocardiographic examination standard plane positions - standard imaging planes three-dimensional reconstruction of echOCardiographic images principles of Doppler flow measurement, principles of flow, and signal processing.
Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy
Daniela Cardinale,Maria T. Sandri,Alessandro Colombo,Nicola Colombo,Marina Boeri,Giuseppina Lamantia,Maurizio Civelli,Fedro A. Peccatori,Giovanni Martinelli,Cesare Fiorentini,Carlo M. Cipolla +10 more
TL;DR: In patients with aggressive malignancies who are undergoing high-dose chemotherapy, even minimal elevation of troponin I (TnI) is associated with late left ventricular dysfunction as discussed by the authors.
Journal ArticleDOI
Myocardial strain measurement with 2-dimensional speckle-tracking echocardiography: definition of normal range.
Thomas H. Marwick,Rodel Leano,Joseph Brown,Jing Ping Sun,Rainer Hoffmann,Peter Lysyansky,Michael Becker,James D. Thomas +7 more
TL;DR: This multicenter study of nearly 250 volunteers without evidence of cardiovascular disease showed an average LV peak systolic strain of -18.6 +/- 0.1% and there was significant segmental variation of regional strain to necessitate the use of site-specific normal ranges.
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